PT  - JOURNAL ARTICLE
AU  - Hugh Middleton
AU  - Joanna Moncrieff
TI  - ‘They won't do any harm and might do some good’: time to think again on the use of antidepressants?
AID  - 10.3399/bjgp11X548983
DP  - 2011 Jan 01
TA  - British Journal of General Practice
PG  - 47--49
VI  - 61
IP  - 582
4099  - http://bjgp.org/content/61/582/47.short
4100  - http://bjgp.org/content/61/582/47.full
SO  - Br J Gen Pract2011 Jan 01; 61
AB  - Despite NICE guidance that should have limited it, antidepressant prescribing continues to increase. Research evidence suggests that much if not all of the observed efficacy should be attributed to complex non-specific effects rather than ‘restoration of disturbed brain chemistry’. According to this view the uncertain benefits of antidepressants are unlikely to outweigh the risks, suggesting the need to explore other approaches to treatment.