RT Journal Article SR Electronic T1 Implications of comorbidity for primary care costs in the UK: a retrospective observational study JF British Journal of General Practice JO Br J Gen Pract FD British Journal of General Practice SP e274 OP e282 DO 10.3399/bjgp13X665242 VO 63 IS 609 A1 Samuel L Brilleman A1 Sarah Purdy A1 Chris Salisbury A1 Frank Windmeijer A1 Hugh Gravelle A1 Sandra Hollinghurst YR 2013 UL http://bjgp.org/content/63/609/e274.abstract AB Background Comorbidity is increasingly common in primary care. The cost implications for patient care and budgetary management are unclear.Aim To investigate whether caring for patients with specific disease combinations increases or decreases primary care costs compared with treating separate patients with one condition each.Design Retrospective observational study using data on 86 100 patients in the General Practice Research Database.Method Annual primary care cost was estimated for each patient including consultations, medication, and investigations. Patients with comorbidity were defined as those with a current diagnosis of more than one chronic condition in the Quality and Outcomes Framework. Multiple regression modelling was used to identify, for three age groups, disease combinations that increase (cost-increasing) or decrease (cost-limiting) cost compared with treating each condition separately.Results Twenty per cent of patients had at least two chronic conditions. All conditions were found to be both cost-increasing and cost-limiting when co-occurring with other conditions except dementia, which is only cost-limiting. Depression is the most important cost-increasing condition when co-occurring with a range of conditions. Hypertension is cost-limiting, particularly when co-occurring with other cardiovascular conditions.Conclusion Three categories of comorbidity emerge, those that are: cost-increasing, mainly due to a combination of depression with physical comorbidity; cost-limiting because treatment for the conditions overlap; and cost-limiting for no apparent reason but possibly because of inadequate care. These results can contribute to efficient and effective management of chronic conditions in primary care.