TY - JOUR T1 - Pointers to earlier diagnosis of endometriosis: a nested case-control study using primary care electronic health records JF - British Journal of General Practice JO - Br J Gen Pract DO - 10.3399/bjgp17X693497 SP - bjgp17X693497 AU - Christopher Burton AU - Lisa Iversen AU - Sohinee Bhattacharya AU - Dolapo Ayansina AU - Lucky Saraswat AU - Derek Sleeman Y1 - 2017/11/07 UR - http://bjgp.org/content/early/2017/11/06/bjgp17X693497.abstract N2 - Background Endometriosis is a condition with relatively non-specific symptoms, and in some cases a long time elapses from first-symptom presentation to diagnosis.Aim To develop and test new composite pointers to a diagnosis of endometriosis in primary care electronic records.Design and setting This is a nested case-control study of 366 cases using the Practice Team Information database of anonymised primary care electronic health records from Scotland. Data were analysed from 366 cases of endometriosis between 1994 and 2010, and two sets of age and GP practice matched controls: (a) 1453 randomly selected females and (b) 610 females whose records contained codes indicating consultation for gynaecological symptoms.Method Composite pointers comprised patterns of symptoms, prescribing, or investigations, in combination or over time. Conditional logistic regression was used to examine the presence of both new and established pointers during the 3 years before diagnosis of endometriosis and to identify time of appearance.Results A number of composite pointers that were strongly predictive of endometriosis were observed. These included pain and menstrual symptoms occurring within the same year (odds ratio [OR] 6.5, 95% confidence interval [CI] = 3.9 to 10.6), and lower gastrointestinal symptoms occurring within 90 days of gynaecological pain (OR 6.1, 95% CI = 3.6 to 10.6). Although the association of infertility with endometriosis was only detectable in the year before diagnosis, several pain-related features were associated with endometriosis several years earlier.Conclusion Useful composite pointers to a diagnosis of endometriosis in GP records were identified. Some of these were present several years before the diagnosis and may be valuable targets for diagnostic support systems. ER -