The effect on symptoms of advice to complete stretching exercises compared to placebo exercises, and advice to stop quinine treatment compared to no such advice.a
| Stretching exercises | P-value | Quinine cessation | P-value | |
|---|---|---|---|---|
| Symptom burden scoreb | 0.02 (−0.35 to 0.38) | 0.93 | 0.04 (−0.33 to 0.40) | 0.85 |
| Night cramps in previous 4 weeks | 1.95 (−3.01 to 6.90) | 0.44 | 3.45 (−1.52 to 8.41) | 0.17 |
| Problems with cramps | 0.02 (−0.42 to 0.46) | 0.92 | 0.30 (−0.14 to 0.74) | 0.17 |
| Quinine tablets used in the previous week | 0.33 (−0.56 to 1.22) | 0.47 | −1.85 (−2.75 to −0.95) | <0.001 |
| Patients stopping quinine treatment (OR)c | 0.73 (0.27–1.98) | 0.54 | 3.32 (1.37–8.06) | 0.008 |
↵a Figures shown are the mean differences estimated from analysis of covariance with 95% CIs unless specified. Analyses used analysis of covariance with 95% CIs for a factorial study to estimate mean differences for continuous outcomes.
↵b Range = 1–7.
c Logistic regression for a factorial study to estimate odds ratios for a dichotomous outcome was used. OR = odds ratio.