Sensitivity, specificity, positive likelihood ratio, and positive predictive value of symptompairs
| Symptom pairs and study | Sensitivity, % (95% CI) | Specificity, % (95% CI) | Positive likelihood ratio, (95% CI) | Positive predictive value, % (95% CI) |
|---|---|---|---|---|
| Rectal bleeding with: | ||||
| Abdominal pain | ||||
| Fijten et al, 199521 | 33 (7.5 to 70.1) | 49 (43.0 to 55.5) | 0.66 (0.26 to 1.67) | 2.22 (0.46 to 6.36) |
| Mant et al, 198922 | 25 (7.3 to 52.4) | 70 (60.8 to 77.4) | 0.82 (0.34 to 1.99) | 9.30 (2.59 to 22.1) |
| Metcalf et al, 199623 | 38 (8.5 to 75.5) | 57 (46.3 to 67.5) | 0.88 (0.35 to 2.21) | 7.14 (1.50 to 19.5) |
| Norrelund and Norrelund, 1996,19 S1 | 31 (16.1 to 50.0) | 78 (71.6 to 84.2) | 1.45 (0.81 to 2.60) | 20.8 (10.5 to 35.0) |
| Norrelund and Norrelund, 1996,19 S2 | 50 (28.2 to 71.8) | 77 (68.8 to 83.7) | 2.16 (1.29 to 3.63) | 26.2 (13.9 to 42.0) |
| Robertson et al, 200624 | 20 (5.7 to 43.7) | 60 (55.8 to 64.0) | 0.50 (0.21 to 1.21) | 1.72 (0.47 to 4.36) |
| Summary estimates | 33 (24.0 to 42.5), I2 = 0.0%, P = 0.42 | 63 (60.1 to 65.3), I2 = 91.3%, P<0.000 | 1.03 (0.63 to 1.69), I2 = 61.1%, P = 0.025 | 7.58 (3.00 to 19.2), I2 = 83.8%, P<0.001 |
| Weight loss | ||||
| Fijten et al, 199521 | 44 (13.7 to 78.8) | 85 (80.5 to 89.4) | 3.04 (1.38 to 6.68) | 9.52 (2.66 to 22.6) |
| Mant et al, 198922 | 13 (1.6 to 38.3) | 91 (84.1 to 95.0) | 1.32 (0.33 to 5.38) | 14.3 (1.78 to 42.8) |
| Metcalf et al, 199623 | 25 (3.2 to 65.1) | 86 (76.8 to 92.2) | 1.75 (0.48 to 6.43) | 13.3 (1.66 to 40.5) |
| Norrelund and Norrelund, 1996,19 S1 | 16 (5.3 to 32.8) | 90 (85.0 to 94.3) | 1.62 (0.64 to 4.07) | 22.7 (7.82 to 45.4) |
| Norrelund and Norrelund, 1996,19 S2 | 23 (7.8 to 45.4) | 87 (80.5 to 92.4) | 1.79 (0.74 to 4.36) | 22.7 (7.82 to 45.4) |
| Robertson et al, 200624 | 14 (2.9 to 34.9) | 90 (86.9 to 92.0) | 1.32 (0.45 to 3.88) | 4.84 (1.01 to 13.5) |
| Summary estimates | 19 (12.3 to 27.9), I2 = 0.0%, P = 0.47 | 89 (86.7 to 90.2), I2 = 1.9%, P = 0.40 | 1.88 (1.25 to 2.83), I2 = 0.0%, P = 0.80 | 13.4 (8.15 to 21.9), I2 = 9.9%, P = 0.35 |
| Change in bowel habit | ||||
| Ellis and Thompson, 200520 | 100 (71.7 to 100.0) | 58 (51.3 to 63.8) | 2.26 (1.88 to 2.72) | 9.24 (4.7 to 15.9) |
| Fijten et al, 199521 | 78 (40.0 to 97.2) | 73 (66.8 to 78.0) | 2.85 (1.91 to 4.26) | 8.97 (3.7 to 17.6) |
| Mant et al, 198922 | 38 (15.2 to 64.6) | 61 (51.6 to 69.2) | 0.95 (0.49 to 1.86) | 10.7 (4.04 to 21.9) |
| Metcalf et al, 199623 | 50 (15.7 to 84.3) | 62 (50.8 to 71.6) | 1.30 (0.62 to 2.72) | 10.3 (2.87 to 24.2) |
| Norrelund and Norrelund, 1996,19 S1 | 59 (40.6 to 76.3) | 77 (69.8 to 82.7) | 2.55 (1.72 to 3.77) | 31.7 (20.6 to 45.0) |
| Norrelund and Norrelund, 1996,19 S2 | 46 (24.4 to 67.8) | 72 (63.2 to 79.1) | 1.60 (0.94 to 2.73) | 20.8 (10.5 to 35.0) |
| Robertson et al, 200624 | 59 (36.4 to 79.3) | 55 (50.6 to 58.9) | 1.31 (0.91 to 1.87) | 4.83 (2.6 to 8.12) |
| Summary estimates | 58 (49.0 to 67.3), I2 = 66.5%, P = 0.006 | 63 (60.4 to 65.1), I2 = 88.0%, P<0.001 | 1.81 (1.33 to 2.46), I2 = 74.6%, P = 0.001 | 11.8 (6.78 to 20.4), I2 = 77.1%, P<0.001 |
| Anaemia | ||||
| Fijten et al, 199521 | 33 (7.5 to 70.1) | 96 (92.6 to 97.9) | 7.88 (2.65 to 23.4) | 21.4 (4.70 to 50.8) |
| Decreased appetite | ||||
| Fijten et al, 199521 | 11 (0.30 to 48.2) | 84 (79.2 to 88.4) | 0.71 (0.11 to 4.57) | 2.4 (0.06 to 12.6) |
| Diarrhoea | ||||
| Metcalf et al, 199623 | 25 (3.20 to 65.1) | 73 (62.2 to 81.4) | 0.91 (0.26 to 3.16) | 7.4 (0.91 to 24.3) |
| Constipation | ||||
| Metcalf et al, 199623 | 13 (0.30 to 52.7) | 58 (47.4 to 68.5) | 0.30 (0.05 to 1.90) | 2.6 (0.07 to 13.5) |
| Peri-anal symptoms | ||||
| Ellis and Thompson, 200520 | 36 (10.9 to 69.2) | 22 (17.0 to 27.5) | 0.47 (0.21 to 1.02) | 2.0 (0.54 to 4.80) |
| Tenesmus | ||||
| Mant et al, 198922 | 13 (1.6 to 38.3) | 78 (70.2 to 85.1) | 0.58 (0.15 to 2.19) | 6.7 (0.82 to 22.1) |