Baseline characteristics of men in the derivation and validation cohorts.
| Derivation cohort (n =1 263 071) | Validation cohort (n =679 174) | |
|---|---|---|
| Mean age (SD) | 48 (16.1) | 47.9 (16.1) |
| BMI recorded, n (%) | 833 205 (66.0) | 432 652 (63.7) |
| Mean BMI (SD) | 26.2 (4.1) | 26.2 (4.1) |
| Mean deprivation score, (SD) | –0.3 (3.4) | –0.1 (3.5) |
| Smoking status, n (%) | ||
| Non-smoker | 475 266 (37.6) | 252 859 (37.2) |
| Ex-smoker | 245 479 (19.4) | 121 964 (18.0) |
| Current: amount not recorded | 46 656 (3.7) | 25 530 (3.8) |
| Light (<10/day) | 82 564 (6.5) | 42 330 (6.2) |
| Moderate (10–19/day) | 90 649 (7.2) | 48 434 (7.1) |
| Heavy (≥20/day) | 74 769 (5.9) | 40 021 (5.9) |
| Smoking not recorded | 247 688 (19.6) | 148 036 (21.8) |
| Alcohol status, n (%) | ||
| None | 169 927 (13.5) | 89 840 (13.2) |
| Trivial <1 unit/day | 271 223 (21.5) | 136 079 (20.0) |
| Light 1–2 units/day | 293 502 (23.2) | 149 000 (21.9) |
| Moderate or heavy ≥3 units/day | 138 294 (10.9) | 70 110 (10.3) |
| Alcohol not recorded | 390 125 (30.9) | 234 145 (34.5) |
| Medical and family history, n (%) | ||
| Prior cancer | 26 884 (2.1) | 13 977 (2.1) |
| Family history of gastrointestinal cancer | 13 201 (1.0) | 6646 (1.0) |
| Family history of prostate cancer | 1323 (0.1) | 654 (0.1) |
| Chronic pancreatitis | 1340 (0.1) | 747 (0.1) |
| Chronic obstructive pulmonary disease | 25 428 (2.0) | 13 217 (1.9) |
| Type 1 diabetes | 4693 (0.4) | 2364 (0.3) |
| Type 2 diabetes | 46719 (3.7) | 25 209 (3.7) |
| Anaemia | 12 046 (1.0) | 6031 (0.9) |
BMI = body mass index. SD = standard deviation.