Characteristic | n | % | n, died:alive | Unadjusted hazard ratio (95% CI) | Adjusted hazard ratioa (95% CI) |
---|---|---|---|---|---|
Age group, years | |||||
<50 | 1750 | 17.4 | 46:1704 | 1.00 | 1.00 |
50–54 | 2724 | 27.1 | 141:2583 | 1.99 (1.43 to 2.78) | 2.02 (1.45 to 2.82) |
55–59 | 2572 | 25.6 | 199:2373 | 3.03 (2.20 to 4.17) | 3.11 (2.25 to 4.29) |
60–64 | 1855 | 18.4 | 228:1627 | 4.92 (3.58 to 6.75) | 4.65 (3.38 to 6.41) |
≥65 | 1158 | 11.5 | 282:876 | 10.45 (7.65 to 14.28) | 9.18 (6.68 to 12.61) |
Social class at recruitment | |||||
Non-manual | 3243 | 32.2 | 276:2967 | 1.00 | 1.00 |
Manual | 6793 | 67.5 | 617:6176 | 1.07 (0.93 to 1.24) | 1.06 (0.91 to 1.22) |
Missing | 23 | 0.2 | 3:20 | 1.56 (0.50 to 4.85) | 2.00 (0.64 to 6.26) |
Parity | |||||
0 | 437 | 4.3 | 53:384 | 1.00 | 1.00 |
1–3 | 5418 | 53.9 | 415:5003 | 0.61 (0.46 to 0.81) | 0.77 (0.58 to 1.03) |
≥4 | 4202 | 41.8 | 428:3774 | 0.83 (0.62 to 1.10) | 0.85 (0.64 to 1.14) |
Missing | 2 | 0.0 | 0:2 | – | – |
History of serious illness | |||||
No | 4862 | 48.3 | 268:4594 | 1.00 | 1.00 |
Yes | 5197 | 51.7 | 628:4569 | 2.27 (1.97 to 2.62) | 1.69 (1.46 to 1.96) |
Number of pack-years smoked | |||||
Never smoked | 5204 | 51.7 | 327:4877 | 1.00 | 1.00 |
≤10 | 1096 | 10.9 | 74:1022 | 1.08 (0.84 to 1.39) | 1.26 (0.98 to 1.62) |
11–20 | 1020 | 10.1 | 105:915 | 1.67 (1.34 to 2.08) | 1.82 (1.46 to 2.27) |
>20 | 2180 | 21.7 | 326:1854 | 2.51 (2.15 to 2.93) | 2.34 (2.00 to 2.74) |
Missing | 559 | 5.6 | 64:495 | 1.88 (1.44 to 2.46) | 1.42 (1.08 to 1.86) |
Number of units of alcohol/week | |||||
Never drinks | 806 | 8.0 | 112:694 | 2.09 (1.69 to 2.58) | 1.66 (1.34 to 2.05) |
<7 | 5504 | 54.7 | 381:5123 | 1.00 | 1.00 |
7–14 | 1381 | 13.7 | 107:1274 | 1.12 (0.91 to 1.39) | 1.10 (0.89 to 1.37) |
>14 | 388 | 3.9 | 40:348 | 1.52 (1.10 to 2.11) | 1.34 (0.97 to 1.87) |
Missing | 1980 | 19.7 | 256:1724 | 1.94 (1.65 to 2.27) | 1.49 (1.26 to 1.75) |
Body mass index, kg/m2 | |||||
<18.50 (underweight) | 92 | 0.9 | 18:74 | 2.62 (1.63 to 4.19) | 1.66 (1.03 to 2.68) |
18.50–24.99 (normal) | 4919 | 48.9 | 407:4512 | 1.00 | 1.00 |
25.00–29.99 (overweight) | 3423 | 34.0 | 306:3117 | 1.08 (0.93 to 1.26) | 0.98 (0.84 to 1.14) |
≥30.00 (obese) | 1468 | 14.6 | 146:1322 | 1.21 (1.00 to 1.46) | 1.03 (0.85 to 1.24) |
Missing | 157 | 1.6 | 19:138 | 1.52 (0.96 to 2.41) | 1.05 (0.66 to 1.66) |
Hours of physical activity/week | |||||
>28 (heavy) | 3231 | 32.1 | 226:3005 | 1.00 | 1.00 |
15–28 (moderate) | 3610 | 35.9 | 271:3339 | 1.08 (0.90 to 1.29) | 1.14 (0.96 to 1.36) |
<15 (light) | 3058 | 30.4 | 368:2690 | 1.79 (1.52 to 2.11) | 1.73 (1.46 to 2.04) |
Missing | 160 | 1.6 | 31:129 | 2.98 (2.05 to 4.34) | 1.73 (1.18 to 2.55) |
↵a Adjusted for age, social class, parity, history of serious illness, pack-years of smoking, weekly alcohol intake, body mass index, and hours of physical activity/week. All variables were assessed at health survey except for social class which was recorded at recruitment to the Oral Contraception Study