Table 5.

Serious mental illness characteristics associated with beta blocker and ACEI/ARB prescribing among patients with coronary heart disease and heart failure

	Beta blockers if recorded with CHD or HF (n = 3347)				ACEI/ARB if recorded with CHD or HF (n = 3760)

	n (%)	Unadjusted OR (95% CI)	Adjusted for sociodemographics OR^{^a} (95% CI)	Additionally adjusted for consultation rate OR^{^b}(95% CI)	n (%)	Unadjusted OR (95% CI)	Adjusted for sociodemographics OR^{^a} (95% CI)	Additionally adjusted for consultation rate OR^{^b} (95% CI)
Non-SMI	3279 (68.3)	1.00	1.00	1.00	3677 (76.6)	1.00	1.00	1.00
SMI overall	68 (52.7)	0.52 (0.36 to 0.73)^{^e}	0.50 (0.35 to 0.73)^{^e}	0.48 (0.33 to 0.69)^{^e}	83 (64.3)	0.55 (0.38 to 0.79)^{^e}	0.49 (0.34 to 0.73)^{^e}	0.42 (0.28 to 0.62)^{^e}

SMI by diagnosis
Schizophrenia	30 (50.0)	0.46 (0.28 to 0.77)^{^d}	0.42 (0.24 to 0.73)^{^d}	0.38 (0.22 to 0.67)^{^e}	36 (60.0)	0.46 (0.27 to 0.77)^{^d}	0.35 (0.20 to 0.60)^{^e}	0.27 (0.15 to 0.48)^{^e}
Bipolar affective disorder	8 (40.0)	0.31 (0.13 to 0.76)^{^c}	0.37 (0.15 to 0.94)^{^c}	0.35 (0.14 to 0.90)^{^c}	11 (55.0)	0.37 (0.15 to 0.90)^{^c}	0.49 (0.18 to 1.26)	0.41 (0.16 to 1.09)
Other non-organic psychoses	8 (61.5)	0.74 (0.24 to 2.27)	0.78 (0.25 to 2.42)	0.75 (0.24 to 2.33)	12 (92.3)	3.66 (0.48 to 28.2)	3.81 (0.49 to 29.4)	3.44 (0.44 to 26.7)

Depot injectable
No	42 (56.8)	0.61 (0.38 to 0.97)^{^c}	0.58 (0.36 to 0.96)^{^c}	0.56 (0.34 to 0.92)^{^c}	48 (64.9)	0.56 (0.35 to 0.91)^{^c}	0.49 (0.29 to 0.81)^{^d}	0.43 (0.26 to 0.72)^{^e}
Yes	11 (36.7)	0.27 (0.13 to 0.57)^{^e}	0.26 (0.12 to 0.60)^{^d}	0.22 (0.09 to 0.52)^{^e}	18 (60.0)	0.46 (0.22 to 0.95)^{^c}	0.41 (0.18 to 0.91)^{^c}	0.32 (0.14 to 0.72)^{^d}

Typical antipsychotic
No	28 (50.9)	0.48 (0.28 to 0.82)^{^d}	0.50 (0.28 to 0.89)^{^c}	0.49 (0.27 to 0.86)^{^c}	34 (61.8)	0.49 (0.29 to 0.85)^{^c}	0.42 (0.23 to 0.75)^{^d}	0.37 (0.21 to 0.67)^{^e}
Yes	25 (51.0)	0.48 (0.27 to 0.85)^{^c}	0.44 (0.24 to 0.81)^{^d}	0.39 (0.21 to 0.73)^{^d}	32 (65.3)	0.57 (0.32 to 1.03)	0.52 (0.28 to 0.97)^{^c}	0.42 (0.22 to 0.80)^{^d}

Atypical antipsychotic
No	8 (87.1)	0.62 (0.21 to 1.78)	0.59 (0.20 to 1.71)	0.54 (0.18 to 1.58)	8 (57.1)	0.41 (0.14 to 1.18)	0.41 (0.14 to 1.20)	0.32 (0.10 to 0.96)^{^c}
Yes	45 (50.0)	0.46 (0.31 to 0.70)^{^e}	0.45 (0.29 to 0.71)^{^e}	0.43 (0.27 to 0.67)^{^e}	58 (64.4)	0.55 (0.36 to 0.86)^{^d}	0.47 (0.30 to 0.76)^{^d}	0.41 (0.26 to 0.66)^{^e}

Any indicator of severity^{^f}
No	45 (57.0)	0.61 (0.39 to 0.96)^{^c}	0.56 (0.35 to 0.91)^{^c}	0.54 (0.33 to 0.87)^{^c}	56 (70.9)	0.74 (0.46 to 1.21)	0.61 (0.37 to 1.01)	0.52 (0.31 to 0.87)^{^c}
Yes	23 (46.0)	0.39 (0.23 to 0.69)^{^e}	0.43 (0.24 to 0.77)^{^d}	0.39 (0.21 to 0.71)^{^d}	27 (54.0)	0.36 (0.20 to 0.63)^{^e}	0.37 (0.20 to 0.66)^{^e}	0.31 (0.17 to 0.56)^{^e}

Any indicator of risk^{^g}
No	54 (59.3)	0.68 (0.44 to 1.03)	0.64 (0.41 to 1.00)	0.61 (0.39 to 0.96)^{^c}	64 (70.3)	0.72 (0.46 to 1.14)	0.65 (0.40 to 1.04)	0.56 (0.35 to 0.91)^{^c}
Yes	14 (36.8)	0.27 (0.14 to 0.52)^{^e}	0.28 (0.14 to 0.57)^{^e}	0.25 (0.12 to 0.51)^{^e}	19 (50.0)	0.31 (0.16 to 0.58)^{^e}	0.27 (0.14 to 0.54)^{^e}	0.22 (0.11 to 0.44)^{^e}

ACEI/ARB = angiotensin-converter enzyme inhibitor/angiotensin receptor blocker. CHD = coronary heart disease. HF = heart failure. OR = odds ratio. SMI = severe mental illness.
↵a Adjusted for age (continuous), sex, ethnic group, borough-level deprivation, and recorded CHD/HF.
↵b Additionally adjusted for mean annual number of primary consultations.
↵c P <0.05.
↵d P <0.01.
↵e P <0.001.
↵f Includes any of: ever had an inpatient stay, any record of being treated under the Mental Health Act, any record of difficulty managing their physical health, or any record of an Assertive Outreach/Crisis/A&E episode.
↵g Includes any of: recorded history of violence, recorded history of non-compliance, and any record of a forensic history.