Table 4.

Sensitivity analyses: net benefit per 10 000 persons for inviting for assessment population with 10-year CVD risk thresholds by effect on diabetes risk and varying statin treatment thresholds^a

Invited, %	Cut-off^{^b}	10-year CVD risk treatment threshold for statins (statins assumed to increase diabetes risk)
Invited, %	Cut-off^{^b}	Net benefit for 10% threshold, £	Net benefit for 15% threshold, £	Net benefit for 20% threshold, £	Net benefit for 25% threshold, £	Net benefit for 7.5% threshold, £
8	0.1276	195 319	188 397	112 700	184 396	167 790
10	0.1142	188 736	183 987	128 576	196 675	179 743
13	0.0983	159 806	172 395	144 537	208 960	193 451
15	0.0896	128 521	171 427	151 326	218 406	199 252
20	0.0721	66 060	178 734	169 385	232 759	212 812
25	0.0590	48 489	181 858	176 995	238 400	215 999
30	0.0488	42 467	181 101	180 853	237 444	215 407
35	0.0406	36 219	174 050	178 669	231 126	210 097
40	0.0339	26 217	162 976	172 179	221 274	200 799
45	0.0283	12 992	150 559	165 075	207 209	187 863
50	0.0236	−3225	132 937	156 436	191 749	172 612
8	Cut-off^{^b} 0.1276	10-year CVD risk treatment threshold for statins (statins assumed not to affect diabetes risk)
8	Cut-off^{^b} 0.1276	420 494	414 083	347 839	245 586	193 065
10	0.1142	478 593	468 227	365 636	259 219	205 668
13	0.0983	550 404	527 239	382 343	273 194	220 312
15	0.0896	585 960	547 727	392 544	283 562	226 582
20	0.0721	647 281	574 502	408 967	299 397	240 952
25	0.0590	668 209	586 376	414 148	306 451	245 221
30	0.0488	675 641	590 219	412 947	306 481	245 441
35	0.0406	675 835	586 021	406 288	300 916	241 082
40	0.0339	670 013	577 154	397 083	291 742	232 443
45	0.0283	659 702	566 787	384 913	278 268	219 889
50	0.0236	645 655	550 856	368 788	263 606	205 184

↵a Invitation based on estimated prior CVD risk versus usual care.
↵b 10-year QRisk threshold above which patients are invited. Benefit based on £20 000 per QALY gained. CVD = cardiovascular disease. QALY = quality-adjusted life year.