Antibiotic prescribing strategy | Poorer global symptomatic outcome^{a} n (%) | Univariate risk ratio (95% CI), P-value | Risk ratio controlling for baseline severity and clustering (95% CI), P-value | Risk ratio controlling for propensity score (95% CI), P-value | Risk ratio controlling for propensity score in imputed dataset (95% CI), P-value |
---|---|---|---|---|---|

None n= 587 | 398 (67.80) | 1.00 | 1.00 | 1.00 | 1.00 |

Immediate n= 728 | 441 (60.58) | 0.88 (0.81 to 0.95), P = 0.002 | 0.81 (0.74 to 0.88), P<0.001 | 0.87 (0.70 to 0.96), P = 0.006 | 0.89 (0.80 to 0.98), P = 0.024 |

Delayed n= 197 | 116 (58.88) | 0.85 (0.75 to 0.97), P = 0.019 | 0.83 (0.73 to 0.95), P = 0.007 | 0.88 (0.78 to 1.00), P = 0.042 | 0.86 (0.74 to 0.97), P = 0.016 |

↵

*a**In the 1512 returning a symptom diary in which the prescribing strategy was detailed.*