Table 1.

Poorer global symptomatic outcome (either greater than median symptom severity in days 2–4 or greater than median duration of symptoms) related to antibiotic strategy and antibiotic type

Antibiotic prescribing strategyPoorer global symptomatic outcomea n (%)Univariate risk ratio (95% CI), P-valueRisk ratio controlling for baseline severity and clustering (95% CI), P-valueRisk ratio controlling for propensity score (95% CI), P-valueRisk ratio controlling for propensity score in imputed dataset (95% CI), P-value
None
n= 587
398 (67.80)1.001.001.001.00
Immediate
n= 728
441 (60.58)0.88 (0.81 to 0.95), P = 0.0020.81 (0.74 to 0.88), P<0.0010.87 (0.70 to 0.96), P = 0.0060.89 (0.80 to 0.98), P = 0.024
Delayed
n= 197
116 (58.88)0.85 (0.75 to 0.97), P = 0.0190.83 (0.73 to 0.95), P = 0.0070.88 (0.78 to 1.00), P = 0.0420.86 (0.74 to 0.97), P = 0.016
  • a In the 1512 returning a symptom diary in which the prescribing strategy was detailed.