Effect of probable streptococcal infection — results for participants with a FeverPAIN scorea of ≥3 according to antibiotic strategy
| Antibiotic prescribing strategy | Poorer global symptomatic outcome, n (%) | Interaction term (95% CI), P-value | Univariate risk ratio (95% CI), P-value | Risk ratio controlling for baseline severity and clustering (95% CI), P-value | Risk ratio controlling for propensity score (95% CI), P-value | Risk ratio controlling for propensity score in imputed dataset (95% CI), P-value |
|---|---|---|---|---|---|---|
| None (reference) n= 20 | 14 (70) | 1.00 | 1.00 | 1.00 | 1.00 | |
| Immediate n= 281 | 152 (54.09) | 0.94 (0.84 to 1.05), P = 0.253 | 0.78 (0.57 to 1.05), P = 0.099 | 0.66 (0.52 to 0.84), P = 0.001 | 0.67 (0.52 to 0.87), P = 0.002 | 0.78 (0.58 to 1.04), P = 0.087 |
| Delayed n= 32 | 18 (56.25) | 0.97 (0.84 to 1.13), P = 0.711 | 0.80 (0.53 to 1.22), P = 0.306 | 0.79 (0.56 to 1.13), P = 0.198 | 0.68 (0.45 to 1.04), P = 0.493 | 0.73 (0.49 to 1.07), P = 0.108 |
↵a FeverPAIN score: 1 point for each of fever in the past 24 hours, purulence, rapid (within 3 days) attendance, inflamed tonsils, and no cough or cold symptoms.