Mixed logistic regression analysis (crude and adjusted analysis) to compare intervention effects on immediate antibiotic prescribing
| Intervention | Crude analysis | Adjusted analysisa,b | ||||||
|---|---|---|---|---|---|---|---|---|
| Immediate prescribing rate | Total prescribing rate | Immediate prescribing rate | Total prescribing rate | |||||
| OR | 95% CI | OR | 95% CI | AOR | 95% CI | AOR | 95% CI | |
| POC CRP | 0.77 | 0.42 to 1.44 | 1.06 | 0.61 to 1.86 | 1.01 | 0.57 to 1.79 | 1.26 | 0.69 to 2.30 |
| BISNA | 1.36 | 0.77 to 2.40 | 1.47 | 0.87 to 2.48 | 2.04 | 1.19 to 3.50 | 1.95 | 1.11 to 3.42 |
| POC CRP + BISNA | 0.99 | 0.54 to 1.84 | 1.07 | 0.61 to 1.88 | 1.17 | 0.66 to 2.09 | 1.21 | 0.66 to 2.22 |
| Usual care (reference group) | ||||||||
↵a Adjusted for region, practice type, baseline antibiotic prescribing, the perceived parental expectation for antibiotics, indication for antibiotics, child’s age, and fever.
↵b 2191 infectious episodes analysed (36 episodes [1.6%] excluded because of missing information about temperature). AOR = adjusted odds ratio. BISNA = brief intervention with safety net. CRP = C-reactive protein. OR = odds ratio. POC = point-of-care.