Differences in colorectal cancer survival between European and US populations: the importance of sub-site and morphology
Introduction
Survival for most of the major adult cancers is higher in the United States of America (USA) than in Europe, especially among the oldest patients [1]. In the USA, 5-year relative survival for patients diagnosed with cancers of the colon and rectum during 1985–1989 were 60 and 57%, respectively, while in Europe the figs. were 48% for colon and 44% for rectum. These differences persisted in all 17 European populations studied, even the most affluent such as Sweden, Switzerland and The Netherlands.
In international comparisons of cancer survival, the anatomical site of the malignancy is usually defined by the three-digit code in the International Classification of Diseases 2, 3, and the morphologic type of the tumours is rarely taken into account. However, survival from some solid tumours is known to vary according to the precise anatomical location (sub-site) within the organ of origin, and by the morphological type of the tumour 4, 5. The distribution of cancers by sub-site and morphology also varies between countries [6].
The aim of this paper was to examine the extent to which anatomical location and morphological type influence the differences in colorectal cancer survival between the USA and Europe.
Section snippets
Patients and methods
The European data were contributed by 40 population-based cancer registries in 17 countries: four from Northern Europe (Iceland, Finland, Sweden and Denmark), four from Eastern Europe (Slovenia, Slovakia, Poland and Estonia), and nine from Western Europe (Scotland, England, The Netherlands, Germany, Austria, Switzerland, France, Italy and Spain) as part of the EUROCARE project 7, 8. The American data were taken from the Surveillance, Epidemiology and End Results (SEER) database, which is
Results
The available data included 160 381 cases of colorectal cancer for Europe and 54 471 cases for the USA. Autopsy-detected cases (0.4% in USA, 0.9% in Europe) were excluded, as were DCO registrations (0.7% in USA, 4.8% in Europe). Total exclusions from the analysis were 9137 cases (5.7%) in Europe and 587 (1.1%) in USA. In all, 205 128 patients were included in the analyses, 151 244 from Europe and 53 884 from the USA (Table 1).
Less than 1% of cases were lost to follow-up the USA (0.9%) or Europe
Discussion
This study has analysed survival for colorectal cancer in Europe and the USA taking into account age, sub-site and morphology code. Stage was unavailable for the majority of European registries so comparisons taking stage into consideration was only performed between the US and those European registries for which stage information was available.
Nevertheless, a major staging indicator is incorporated into the morphology code adenocarcinoma in polyps. Therefore, adjusting for morphology also
The EUROCARE Working Group for this study
Austria: W. Oberaigner (Cancer Registry of Tyrol); Denmark: H.H. Storm (Danish Cancer Society); Estonia: T. Aareleid (Estonian Cancer Registry); Finland: T. Hakulinen (Finnish Cancer Registry); France: H. Lefevre (Calvados Digestive Cancer Registry), J. MaceLesec'h (Calvados General Cancer Registry), P. Arveux (Doubs Cancer Registry), H. Mathieu-Daude' (Herault Cancer Registry) N. Raverdy (Somme Cancer Registry); Germany: H. Ziegler (Saarland Cancer Registry); Iceland: L. Tryggvadottir
Acknowledgments
This work would not have been possible without the sustained effort over many years of cancer registries across Europe, and we are extremely grateful for their co-operation. The EUROCARE study was financed through the BIOMED Programme of the European Community. This study was also financed by the ‘Europe against Cancer' programme (project number S 12.117414 ‘Differences in the survival of colorectal cancer patients between Europe and USA'). The authors are grateful to Emily Taussig for
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2016, Cancer EpidemiologyCitation Excerpt :For all these reasons, replication of this study in other Spanish cancer registries seems desirable. Our study also adds new evidence concerning the deleterious effect on survival of colorectal cancer of mucinous adenocarcinoma histology [19], whereas no differences were found between adenocarcinoma NOS or adenocarcinoma on polyp—supposedly an early stage of adenocarcinoma, and thus with better survival [20]. MI of unknown stage has been recommended [21], and used increasingly by some authors [22,23], but not by others [24], who keep the unknown category while trying to reduce it by making some assumptions, such as assigning Dukes A stage to patients who have undergone endoscopic polypectomy, or Dukes D to cases that have undergone palliative surgery.
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