What drives proteins into the major or minor grooves of DNA?
PL Privalov, AI Dragan, C Crane-Robinson… - Journal of molecular …, 2007 - Elsevier
The energetic profiles of a significant number of protein–DNA systems at 20 C reveal that,
despite comparable Gibbs free energies, association with the major groove is primarily an …
despite comparable Gibbs free energies, association with the major groove is primarily an …
Microcalorimetry of biological macromolecules
PL Privalov, AI Dragan - Biophysical chemistry, 2007 - Elsevier
The capabilities of contemporary differential scanning and isothermal titration microcalorimetry
for studying the thermodynamics of protein unfolding/refolding and their association with …
for studying the thermodynamics of protein unfolding/refolding and their association with …
Interpreting protein/DNA interactions: distinguishing specific from non-specific and electrostatic from non-electrostatic components
PL Privalov, AI Dragan… - Nucleic acids …, 2011 - academic.oup.com
We discuss the effectiveness of existing methods for understanding the forces driving the
formation of specific protein–DNA complexes. Theoretical approaches using the Poisson–…
formation of specific protein–DNA complexes. Theoretical approaches using the Poisson–…
Continued high rates of antibiotic prescribing to adults with respiratory tract infection: survey of 568 UK general practices
Objectives Overutilisation of antibiotics may contribute to the emergence of antimicrobial drug
resistance, a growing international concern. This study aimed to analyse the performance …
resistance, a growing international concern. This study aimed to analyse the performance …
[HTML][HTML] Prevalence and variability of current depressive disorder in 27 European countries: a population-based study
Background We aimed to estimate the prevalence of current depressive disorder in 27
European countries, and to explore differences in prevalence between European countries and …
European countries, and to explore differences in prevalence between European countries and …
Systolic blood pressure trajectory, frailty, and all-cause mortality> 80 years of age: cohort study using electronic health records
…, S Hamada, J Charlton, SHD Jackson, A Dregan… - Circulation, 2017 - Am Heart Assoc
Background: Clinical trials show benefit from lowering systolic blood pressure (SBP) in people
≥80 years of age, but nonrandomized epidemiological studies suggest lower SBP may …
≥80 years of age, but nonrandomized epidemiological studies suggest lower SBP may …
Chronic inflammatory disorders and risk of type 2 diabetes mellitus, coronary heart disease, and stroke: a population-based cohort study
A Dregan, J Charlton, P Chowienczyk, MC Gulliford - Circulation, 2014 - Am Heart Assoc
Background— This study sought to evaluate whether risks of diabetes mellitus and
cardiovascular disease are elevated across a range of organ-specific and multisystem chronic …
cardiovascular disease are elevated across a range of organ-specific and multisystem chronic …
Cardiovascular risk factors and cognitive decline in adults aged 50 and over: a population-based cohort study
Objectives: the objective of the present study was to explore the association between
cardiovascular risk and cognitive decline in adults aged 50 and over. Methods: participants were …
cardiovascular risk and cognitive decline in adults aged 50 and over. Methods: participants were …
Foster care, residential care and public care placement patterns are associated with adult life trajectories: population-based cohort study
A Dregan, MC Gulliford - Social psychiatry and psychiatric epidemiology, 2012 - Springer
Objectives Childhood experiences of public care may be associated with adult psychosocial
outcomes. This study aimed to evaluate the associations of four public care exposures: type …
outcomes. This study aimed to evaluate the associations of four public care exposures: type …
Chomp: Covariant hamiltonian optimization for motion planning
In this paper, we present CHOMP (covariant Hamiltonian optimization for motion planning),
a method for trajectory optimization invariant to reparametrization. CHOMP uses functional …
a method for trajectory optimization invariant to reparametrization. CHOMP uses functional …