Background: Following the spread of the coronavirus disease 2019 (COVID-19) pandemic a
new disease entity emerged, defined as Pediatric Inflammatory Multisystem Syndrome …

Newborn screening (NBS) is a population-based program with a goal of reducing the burden
of disease for conditions with significant clinical impact on neonates. Screening tests were …

Most great ape genetic variation remains uncharacterized 1 , 2 ; however, its study is critical
for understanding population history 3 , 4 , 5 , 6 , recombination 7 , selection 8 and …

Protein aggregation is linked with neurodegeneration and numerous other diseases by
mechanisms that are not well understood. Here, we have analyzed the gain-of-function toxicity of …

Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal
rearrangement and occupy a key node in the primate phylogeny between Old World …

A long-debated question concerns the fate of archaic forms of the genus Homo: did they go
extinct without interbreeding with anatomically modern humans, or are their genes present in …

Amyloid-like protein aggregation is associated with neurodegeneration and other pathologies.
The nature of the toxic aggregate species and their mechanism of action remain elusive. …

Neanderthals were a group of archaic hominins that occupied most of Europe and parts of
Western Asia from ∼30,000 to 300,000 years ago (KYA). They coexisted with modern …

Formation of aberrant protein conformers is a common pathological denominator of different
neurodegenerative disorders, such as Alzheimer's disease or prion diseases. Moreover, …

We report the discovery of an African American Y chromosome that carries the ancestral
state of all SNPs that defined the basal portion of the Y chromosome phylogenetic tree. We …