Background Neuraminidase inhibitors (NIs) are stockpiled and recommended by public
health agencies for treating and preventing seasonal and pandemic influenza. They are used …

Objective To describe the potential benefits and harms of oseltamivir by reviewing all clinical
study reports (or similar document when no clinical study report exists) of randomised …

Background There have been no studies of the patterns of post-marketing withdrawals of
medicinal products to which adverse reactions have been attributed. We identified medicinal …

… Our original review (Heneghan 2006) has been cited in joint guidance from the National
Institute of Clinical Excellence (NICE, UK) and Royal College of General Practitioners RCGP, UK…

Background Neuraminidase inhibitors (NI) are recommended for use against influenza and
its complications in inter‐pandemic years and during pandemics. Objectives To assess the …

Background The introduction of portable monitors (point‐of‐care devices) for the management
of patients on oral anticoagulation allows self‐testing by the patient at home. Patients who …

OBJECTIVE Middle-aged people with diabetes have been reported to have significantly
higher risks of cardiovascular events than people without diabetes. However, recent falls in …

Objective The use of antibiotic prophylaxis (AP) for prevention of infective endocarditis (IE)
is controversial. In recent years, guidelines to cardiologists and dentists have advised …

Background This is an update of a Cochrane review first published in The Cochrane Library
in Issue 4, 2006. Otitis media with e usion (OME) or'glue ear'is an accumulation of fluid in the …

… Carl J Heneghan professor of evidence based medicine1, Igho Onakpoya research fellow
in evidence based practice and pharmacovigilance1, Matthew Thompson Helen D Cohen …