Infants of mothers treated for tuberculosis might be exposed to drugs via breast milk. The
existing information on the exposure of breastfed infants lacks a critical review of the published …

Background Statins substantially reduce the risk of cardiovascular disease when taken
regularly. Though statins are generally well tolerated, current studies show that one-third of …

Physiologically based kinetic (PBK) modeling has been increasingly used since the beginning
of the 21st century to support dose selection to be used in preclinical and clinical safety …

Observational studies report a strong positive linear association between alcohol consumption
and blood pressure but also suggested a lower cardiovascular risk with light drinking …

Background The acetylcholinesterase inhibitors (AChEIs) donepezil, galantamine, and
rivastigmine are commonly used in the management of various forms of dementia. Objectives …

Introduction: Epidemiological studies in children suggested that in utero exposure to chlorpyrifos
(CPF), an organophosphate insecticide, may cause developmental neurotoxicity (DNT). …

Aim: To measure the extent of polypharmacy, multimorbidity and potential medication-related
problems in elderly patients with chronic pain receiving home care. Methods: Data of 355 …

Systemic arterial hypertension (referred to as hypertension herein) is a major risk factor of
mortality worldwide, and its importance is further emphasized in the context of the novel …

In vitro studies are increasingly proposed to replace in vivo toxicity testing of substances. We
set out to apply physiologically based pharmacokinetic (PBPK) modeling to predict the in …

Amiodarone is an antiarrhythmic agent inducing adverse effects on the nervous system,
among others. We applied physiologically based pharmacokinetic (PBPK) modeling combined …