Trimethylamine and trimethylamine N-oxide, a flavin-containing monooxygenase 3 (FMO3)-mediated host-microbiome metabolic axis implicated in health and disease
D Fennema, IR Phillips, EA Shephard - Drug Metabolism and Disposition, 2016 - ASPET
Flavin-containing monooxygenase 3 (FMO3) is known primarily as an enzyme involved in
the metabolism of therapeutic drugs. On a daily basis, however, we are exposed to one of the …
the metabolism of therapeutic drugs. On a daily basis, however, we are exposed to one of the …
Flavin-containing monooxygenases: mutations, disease and drug response
IR Phillips, EA Shephard - Trends in pharmacological sciences, 2008 - cell.com
Flavin-containing monooxygenases (FMOs) metabolize numerous foreign chemicals,
including drugs, pesticides and dietary components and, thus, mediate interactions between …
including drugs, pesticides and dietary components and, thus, mediate interactions between …
Drug metabolism by flavin-containing monooxygenases of human and mouse
IR Phillips, EA Shephard - Expert opinion on drug metabolism & …, 2017 - Taylor & Francis
Introduction: Flavin-containing monooxygenases (FMOs) play an important role in drug
metabolism. Areas covered: We focus on the role of FMOs in the metabolism of drugs in human …
metabolism. Areas covered: We focus on the role of FMOs in the metabolism of drugs in human …
Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome
CT Dolphin, A Janmohamed, RL Smith, EA Shephard… - Nature …, 1997 - nature.com
Individuals with primary trimethylaminuria exhibit a body odour reminiscent of rotting fish, due
to excessive excretion of trimethylamine (TMA; refs 1–3). The disorder, colloquially known …
to excessive excretion of trimethylamine (TMA; refs 1–3). The disorder, colloquially known …
[HTML][HTML] A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments
AC Dona, M Kyriakides, F Scott, EA Shephard… - Computational and …, 2016 - Elsevier
Metabonomics/metabolomics is an important science for the understanding of biological
systems and the prediction of their behaviour, through the profiling of metabolites. Two …
systems and the prediction of their behaviour, through the profiling of metabolites. Two …
A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities
…, LL Poulsen, AE Rettie, EA Shephard… - Archives of Biochemistry …, 1994 - Elsevier
A nomenclature based on comparisons of amino acid sequences is proposed for the
members of the mammalian flavin-containing monooxygenase (FMO) gene family. This …
members of the mammalian flavin-containing monooxygenase (FMO) gene family. This …
Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters
…, P Chandan, IR Phillips, EA Shephard - Pharmacogenetics …, 2004 - journals.lww.com
Objectives To date, six flavin-containing monooxygenase (FMO) genes have been identified
in humans, FMOs 1, 2, 3, 4 and 6, which are located within a cluster on chromosome 1, and …
in humans, FMOs 1, 2, 3, 4 and 6, which are located within a cluster on chromosome 1, and …
[BOOK][B] Cell biology: a short course
SR Bolsover, EA Shephard, HA White, JS Hyams - 2011 - books.google.com
CELL BIOLOGY The ultimate concise introduction to modern cell biology, now updated Taking
an “essentials only” approach, Cell Biology: A Short Course, Third Edition tells the story of …
an “essentials only” approach, Cell Biology: A Short Course, Third Edition tells the story of …
The molecular biology of the flavin-containing monooxygenases of man
…, RR McCombie, RL Smith, EA Shephard - Chemico-biological …, 1995 - Elsevier
… Vercruysse, EA Shephard and IR Phillips, Maintenance and induction in co-cultured rat …
CNA Palmer, EA Shephard and IR Phillips, Inter-individual variation in the expression of …
CNA Palmer, EA Shephard and IR Phillips, Inter-individual variation in the expression of …
Review and validation of Bayesian dose‐optimizing software and equations for calculation of the vancomycin area under the curve in critically ill patients
RB Turner, K Kojiro, EA Shephard… - … : The Journal of …, 2018 - Wiley Online Library
Background Vancomycin area under the concentration‐time curve (AUC) has been linked
to efficacy and safety. An accurate method of calculating the AUC is needed. Methods …
to efficacy and safety. An accurate method of calculating the AUC is needed. Methods …