Estrogen receptor (ER) binds to estrogen response elements in target genes and recruits a
coactivator complex of CBP-pl60 that mediates stimulation of transcription. ER also activates …

We report on 44 patients (18 with additional affected family members), with con genital distal
limb contractures identified from a large study of over 350 patients with congenital joint …

The decay of the free neutron into a proton, electron, and antineutrino is the prototype
semileptonic weak decay and is the simplest example of nuclear beta decay. It played a key role in …

The Sloan Digital Sky Survey (SDSS) is an imaging and spectroscopic survey that will
eventually cover approximately one-quarter of the celestial sphere and collect spectra of≈ 10 6 …

Oestrogens are involved in the growth, development and homeostasis of a number of tissues
1 . The physiological effects of these steroids are mediated by a ligand-inducible nuclear …

Ligand-dependent activation of transcription by nuclear receptors (NRs) is mediated by
interactions with coactivators. Receptor agonists promote coactivator binding, and antagonists …

The mechanism by which the estrogen receptor and other steroid hormone receptors regulate
gene expression in eukaryotic cells is not well understood. In this study, a complementary …

Although it is widely accepted that specific intracellular receptor proteins are involved in the
oestrogenic regulation of gene expression and growth in reproductive tissues, the precise …

… However, here we show that G proteins and adenylate cyclase are activated by 17-β-E 2
in membrane preparations and, according to current knowledge, this cannot result from …

Seventy percent of breast cancers express estrogen receptor (ER), and most of these are
sensitive to ER inhibition. However, many such tumors for unknown reasons become refractory …