[HTML][HTML] Global prevalence of chronic kidney disease–a systematic review and meta-analysis
NR Hill, ST Fatoba, JL Oke, JA Hirst, CA O'Callaghan… - PloS one, 2016 - journals.plos.org
Chronic kidney disease (CKD) is a global health burden with a high economic cost to health
systems and is an independent risk factor for cardiovascular disease (CVD). All stages of …
systems and is an independent risk factor for cardiovascular disease (CVD). All stages of …
Impact of patient and public involvement on enrolment and retention in clinical trials: systematic review and meta-analysis
JC Crocker, I Ricci-Cabello, A Parker, JA Hirst, A Chant… - bmj, 2018 - bmj.com
Objective To investigate the impact of patient and public involvement (PPI) on rates of enrolment
and retention in clinical trials and explore how this varies with the context and nature of …
and retention in clinical trials and explore how this varies with the context and nature of …
Cell type–specific expression profiling in plants via cell sorting of protoplasts from fluorescent reporter lines
…, JW Jung, JY Wang, GM Lambert, JA Hirst… - Nature …, 2005 - nature.com
To investigate the relationship between developmental events and gene expression, cell-specific
resolution of gene activity is critical. Such high-resolution data have been difficult to …
resolution of gene activity is critical. Such high-resolution data have been difficult to …
[HTML][HTML] Estimating the effect of sulfonylurea on HbA1c in diabetes: a systematic review and meta-analysis
Aims/hypothesis Sulfonylureas are widely prescribed glucose-lowering medications for
diabetes, but the extent to which they improve glycaemia is poorly documented. This systematic …
diabetes, but the extent to which they improve glycaemia is poorly documented. This systematic …
Clinical and angiographic characteristics of exertion-related acute myocardial infarction
…, FJ Kiernan, J Clive, DB Fram, JF Mitchel, JA Hirst… - Jama, 1999 - jamanetwork.com
ContextVigorous physical exertion transiently increases the risk of acute myocardial
infarction (MI), but little is known about the clinical characteristics of exertion-related MI.ObjectiveTo …
infarction (MI), but little is known about the clinical characteristics of exertion-related MI.ObjectiveTo …
Quantifying the effect of metformin treatment and dose on glycemic control
OBJECTIVE Metformin is the first-line oral medication recommended for glycemic control in
patients with type 2 diabetes. We reviewed the literature to quantify the effect of metformin …
patients with type 2 diabetes. We reviewed the literature to quantify the effect of metformin …
[HTML][HTML] The need for randomization in animal trials: an overview of systematic reviews
… The protocol (unpublished) was finalized by JH, CH, RP, and JA in October 2012. We
modified the protocol once to add the secondary analysis (testing the “unpredictability paradox”; …
modified the protocol once to add the secondary analysis (testing the “unpredictability paradox”; …
[HTML][HTML] Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials
Aims/hypothesis Observational studies suggest that metformin may reduce cancer risk by
approximately one-third. We examined cancer outcomes and all-cause mortality in published …
approximately one-third. We examined cancer outcomes and all-cause mortality in published …
[HTML][HTML] Performance of point-of-care HbA1c test devices: implications for use in clinical practice – a systematic review and meta-analysis
JA Hirst, JH McLellan, CP Price, E English… - Clinical Chemistry and …, 2017 - degruyter.com
Background: Point-of-care (POC) devices could be used to measure hemoglobin A 1c (HbA
1c ) in the doctors’ office, allowing immediate feedback of results to patients. Reports have …
1c ) in the doctors’ office, allowing immediate feedback of results to patients. Reports have …
Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse
P Kisielow, JA Hirst, H Shiku, PCL Beverley… - Nature, 1975 - nature.com
THYMUS-DERIVED lymphocytes (T cells) have several functions 1–3 , and in some instances
it appears that two sub-populations of T cells interact to amplify their response 4,5 . But …
it appears that two sub-populations of T cells interact to amplify their response 4,5 . But …