Human skin, like all other organs, undergoes chronological aging. In addition, unlike other
organs, skin is in direct contact with the environment and therefore undergoes aging as a …

UV radiation from the sun impacts skin health adversely through complex, multiple molecular
pathways. Premature skin aging (photoaging) is among the most widely appreciated …

Skin appearance is a primary indicator of age. During the last decade, substantial progress
has been made toward understanding underlying mechanisms of human skin aging. This …

DAMAGE to skin collagen and elastin (extracellular matrix) is the hallmark of long-term
exposure to solar ultraviolet irradiation 1–3 , and is believed to be responsible for the wrinkled …

Background Long-term exposure to ultraviolet irradiation from sunlight causes premature
skin aging (photoaging), characterized in part by wrinkles, altered pigmentation, and loss of …

Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To
identify psoriasis susceptibility loci, we genotyped 438,670 SNPs in 1,409 psoriasis cases …

To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis
of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped …

Reduced synthesis of collagen types I and III is characteristic of chronologically aged skin.
The present report provides evidence that both cellular fibroblast aging and defective …

Damage to human skin due to ultraviolet light from the sun (photoaging) and damage occurring
as a consequence of the passage of time (chronologic or natural aging) are considered …

We examined the role of circulating autoantibodies in the pathogenesis of pemphigus
vulgaris by passively transferring IgG fractions from five patients with pemphigus vulgaris into …