Despite major improvements in outcome over the past decades, acute myeloid leukemia (AML)
remains a life-threatening malignancy in children, with current survival rates of ∼ 70%. …

Diagnosis, treatment, response monitoring, and outcome of pediatric acute myeloid leukemia
(AML) have made enormous progress during the past decades. Because AML is a rare …

The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG)
has developed a new protocol for the diagnosis and treatment of childhood renal …

Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant,
pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained …

Chromosomal rearrangements of the human MLL (mixed lineage leukemia) gene are
associated with high-risk infant, pediatric, adult and therapy-induced acute leukemias. We used …

Chromosomal rearrangements of the human MLL gene are associated with high-risk
pediatric, adult and therapy-associated acute leukemias. These patients need to be identified, …

Translocations involving chromosome 11q23 frequently occur in pediatric acute myeloid
leukemia (AML) and are associated with poor prognosis. In most cases, the MLL gene is …

CBL encodes a member of the Cbl family of proteins, which functions as an E3 ubiquitin ligase.
We describe a dominant developmental disorder resulting from germline missense CBL …

Allogeneic hematopoietic stem cell transplantation (HSCT) is the only proven curative
therapy for juvenile myelomonocytic leukemia (JMML). We, the European Working Group on …

Adult stem cell-derived organoids are three-dimensional epithelial structures that
recapitulate fundamental aspects of their organ of origin. We describe conditions for the long-term …