INTRODUCTION The emergence of three lethal coronaviruses in <20 years and the urgency
of the COVID-19 pandemic have prompted efforts to develop new therapeutic strategies, …

Objective To assess how pressures from patients on doctors in the consultation contribute to
referral and investigation. Design Observational study nested within a randomised …

The recent emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2),
the underlying cause of Coronavirus Disease 2019 (COVID-19), has led to a worldwide …

Sphingolipid biosynthesis commences with the condensation of L-serine and palmitoyl-CoA
to produce 3-ketodihydrosphingosine (KDS). This reaction is catalysed by the PLP-…

The Scottish Structural Proteomics Facility was funded to develop a laboratory scale
approach to high throughput structure determination. The effort was successful in that over 40 …

10.7554/eLife.50416.001 Mutations that activate LRRK2 protein kinase cause Parkinson’s
disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif …

Objective To assess the impact of leaflets encouraging patients to raise concerns and to
discuss symptoms or other health related issues in the consultation. Design Randomised …

… While a further eight plants were supplied with the nutrient solution detailed above, but
containing 2 mol m −3 NO 3 (1 mol m −3 KNO 3 and 1 mol m −3 NaNO 3 ) to compartment A and …

… P Little, BA, MSc, MD, FRCGP, MRCP, professor of primary care research; M Dorward,
research nurse; S Gralton, MB BS, medical student; L Hammerton, MB BS, medical student, …

… 300 to 800 m/z mass range was acquired at 120 000 at 200 m/z resolution and a PRM scan
was acquired at 30 000 at 200 m/z resolution. The quadrupole isolation width of 0.7 m/z was …