User profiles for T. Afzali

tamana afzali

The Research Unit for General Practice in Aalborg
Verified email at dcm.aau.dk
Cited by 66

[HTML][HTML] Cost-effectiveness of treatments for non-osteoarthritic knee pain conditions: A systematic review

T Afzali, MV Fangel, AS Vestergaard, MS Rathleff… - PLoS …, 2018 - journals.plos.org
Introduction Knee pain is common in adolescents and adults and is associated with an
increased risk of developing knee osteoarthritis. The aim of this systematic review was to gather …

Effect of differentiating exercise guidance based on a patient's level of low back pain in primary care: a mixed-methods systematic review protocol

JE Jorgensen, T Afzali, A Riis - BMJ open, 2018 - bmjopen.bmj.com
Introduction Low back pain (LBP) is one of the health conditions that lead to the most disability
worldwide. Guidelines aimed at management of LBP recommend non-invasive and non-…

The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease

B Afzali, G Lombardi, RI Lechler… - Clinical & Experimental …, 2007 - academic.oup.com
… , T-bet for Th1, GATA-3 for Th2, forkhead box P3 (FoxP3) for T regs and RORγt for Th17 cells.
Recently, it has been demonstrated that the skewing of murine Thp towards Th17 and TT

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

…, J Köhl, P Monk, MA Cooper, M Arno, B Afzali… - Science, 2016 - science.org
… for complement C3 also in human T cell immunity: The … T cell lineage commitment, and
they control initiation and resolution of T helper 1 (T H 1) responses in an autocrine fashion via T

[PDF][PDF] Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation

…, M Ma, A Cope, T Reinheckel, SR de Cordoba, B Afzali… - Immunity, 2013 - cell.com
T cell-expressed protease cathepsin L (CTSL) processed C3 into biologically active C3a and
C3b. Resting T … While "tonic" intracellular C3a generation was required for homeostatic T

IL‐17‐producing CD4+ T cells, pro‐inflammatory cytokines and apoptosis are increased in low risk myelodysplastic syndrome

SY Kordasti, B Afzali, Z Lim, W Ingram… - British journal of …, 2009 - Wiley Online Library
… CD8 + T cells in all subtypes of MDS, we speculated that the mechanism of inflammatory
response in low risk MDS might be correlated with an increased number of pro-inflammatory T-…

CD4+CD25high Foxp3+ regulatory T cells in myelodysplastic syndrome (MDS)

…, J Hayden, D Darling, L Barber, B Afzali… - Blood, The Journal …, 2007 - ashpublications.org
Foxp3 + regulatory T cells (Tregs) play a central role in maintaining immune tolerance. A
reduction in the function of Tregs is a key feature of autoimmune diseases, whereas their …

Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells

B Afzali, P Mitchell, RI Lechler, S John… - Clinical & …, 2010 - academic.oup.com
… towards T helper type 1 (Th1), Th2, Th17 and regulatory T cell (T reg … T-bet for Th1, GATA-3
for Th2, forkhead box P3 (FoxP3) for T … In this paper, we review T reg to Th17 conversion and …

CD 161 expression characterizes a subpopulation of human regulatory T cells that produces IL‐17 in a STAT 3‐dependent manner

B Afzali, PJ Mitchell, FC Edozie… - European journal of …, 2013 - Wiley Online Library
T reg cells from patients with STAT 3 mutations unable to make IL ‐17. Finally, we show that
CD 161 + population III TT reg‐cell population at these sites. As IL ‐17 production from this …

Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease

…, JD Sanderson, JK Howard, S Yagel, B Afzali… - Gut, 2016 - gut.bmj.com
Background and aim Thymus-derived regulatory T cells (T regs ) mediate dominant peripheral
tolerance and treat experimental colitis. T regs can be expanded from patient blood and …