… Two such proteins are the linkers for the activation of T and B cells (LAT and LAB; LAB is
also known as LAT2 and NTAL) [91]. While they share most functions, a key difference is that …

Familial hypercholesterolaemia (FH) is a dominant and highly penetrant monogenic
disorder present from birth that markedly elevates plasma low-density lipoprotein (LDL)-cholesterol …

… The pathogenesis of this equine disease also involves T helper type 2 (Th2) cytokine
production (especially IL-4 and IL-13) (66). Furthermore, as in the airway disease that develops in …

During antiviral defense, interferon (IFN) signaling triggers nuclear transport of tyrosine-phosphorylated
STAT1 (PY-STAT1), which occurs via a subset of karyopherin alpha (KPNA) …

Increased mucus production is a common cause of morbidity and mortality in inflammatory
airway diseases, including asthma, chronic obstructive pulmonary disease (COPD), and …

Enhancing the response to interferon could offer an immunological advantage to the host. In
support of this concept, we used a modified form of the transcription factor STAT1 to achieve …

Viral infections and type 2 immune responses are thought to be critical for the development
of chronic respiratory disease, but the link between these events needs to be better defined. …

… Real-time data were analyzed by the comparative C T method. Average C T values for each
sample were normalized to the average C T values for the housekeeping gene GAPDH. The …

10.7554/eLife.20391.001 Genetic variations in the myeloid immune receptor TREM2 are
linked to several neurodegenerative diseases. To determine how TREM2 variants contribute to …

Clathrin-mediated endocytosis depends upon the interaction of accessory proteins with the
α-ear of the AP-2 adaptor. We present structural characterization of these regulatory …