Single-cell transcriptomics to explore the immune system in health and disease

MJT Stubbington, O Rozenblatt-Rosen, A Regev… - Science, 2017 - science.org
… Immune cells pose a further challenge: Lymphocytes with particular antigen receptor
sequences [such as classical T and B cells but also invariant natural killer T (iNKT) cells, γδ …

Food bolus and oesophageal foreign body: a summary of the evidence and proposed management process

TJ Stubington, T Kamani - European Archives of Oto-Rhino-Laryngology, 2021 - Springer
Purpose Food bolus and oesophageal foreign bodies are a common presentation that may
be managed by otolaryngologists, gastroenterologists, acute medicine physicians and …

Tracheotomy in COVID‐19 patients: optimizing patient selection and identifying prognostic indicators

TJ Stubington, AS Mallick, G Garas, E Stubington… - Head & …, 2020 - Wiley Online Library
Background Tracheotomy, through its ability to wean patients off ventilation, can shorten ICU
length of stay and in doing so increase ICU bed capacity, crucial for saving lives during the …

The human cell atlas

…, JW Shin, O Stegle, M Stratton, MJT Stubbington… - elife, 2017 - elifesciences.org
… In humans, immune cells naturally contain lineage barcodes through VDJ recombination in
T and B cells and somatic hypermutation in B cells (Stubbington et al., 2016). More generally, …

Single-cell reconstruction of the early maternal–fetal interface in humans

…, DH Rowitch, JN Bulmer, GJ Wright, MJT Stubbington… - Nature, 2018 - nature.com
… We studied T cell composition and clonal expansion using full-length transcriptomes from …
the T cell receptor sequences from this data, which showed expansion of CD8 T cells in the …

[HTML][HTML] A psittacosis outbreak among english office workers with little or no contact with birds, august 2015

…, T Lamming, A Dziadosz, D Flecknoe, T Stubington… - PLoS …, 2018 - ncbi.nlm.nih.gov
Methods: We undertook case finding for self-reported pneumonia cases at local businesses
(July-August 2015). Clinical samples from a hospitalised case were tested for common …

T cell fate and clonality inference from single-cell transcriptomes

MJT Stubbington, T Lönnberg, V Proserpio, S Clare… - Nature …, 2016 - nature.com
… that T cell clonotypes in a mouse Salmonella infection model span early activated CD4 + T
… We analyzed the expression of 259 genes that indicate a T H 1 cell fate 22 , as well as Il7r (…

Decoding human fetal liver haematopoiesis

…, A Fuller, B Millar, B Innes, S Lindsay, MJT Stubbington… - Nature, 2019 - nature.com
… The early lymphoid/T lymphocyte cluster varied by gestational stage, with cells expressing
GATA3, KLRB1, CD3D, CD7 and JCHAIN at 7–8 PCW before T cells emerged from the …

[HTML][HTML] The Human Cell Atlas: from vision to reality

O Rozenblatt-Rosen, MJT Stubbington, A Regev… - Nature, 2017 - nature.com
… As a result, there are many cell types we don’t know about. We also don’t know how all the
cells in the body change from one state to another, which other cells they interact with or how …

[HTML][HTML] Circulating and tissue-resident CD4+ T cells with reactivity to intestinal microbiota are abundant in healthy individuals and function is altered during …

AN Hegazy, NR West, MJT Stubbington, E Wendt… - Gastroenterology, 2017 - Elsevier
… + T cells were reduced in the blood compared with intestine; T-cell responses that we detected
had an increased frequency of interleukin 17A production compared with responses of T