Prostaglandins as inflammatory messengers across the blood-brain barrier

D Engblom, M Ek, S Saha… - Journal of molecular …, 2002 - Springer
… (D. Engblom et al., unpublished data) contain EP3 receptors. This supports a role for EP3
receptor-bearing neurons in the modulation of a variety of autonomic functions, including …

Neural mechanisms of inflammation-induced fever

A Blomqvist, D Engblom - The Neuroscientist, 2018 - journals.sagepub.com
Fever is a common symptom of infectious and inflammatory disease. It is well-established
that prostaglandin E 2 is the final mediator of fever, which by binding to its EP 3 receptor …

Pathway across the blood–brain barrier

M Ek, D Engblom, S Saha, A Blomqvist, PJ Jakobsson… - Nature, 2001 - nature.com
d, No microsomal PGES messenger RNA was induced in control animals injected with
saline (at 3 hours post-injection). Method specificity was confirmed by the absence of …

Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1

…, G Von Wolff, C Avrabos, C Touma, D Engblom… - Science, 2011 - science.org
… (D to F) CRH enhances neuronal activity propagation via CRHR1 on Glu neurons by
amplifying neuronal excitation on its passage through the HF. (D) Time courses of experiments …

Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc

M Mameli, B Halbout, C Creton, D Engblom… - Nature …, 2009 - nature.com
… Because we established that 7 d is normally enough for a full reversal of cocaine-evoked
plasticity, we cut slices on day 8 and found that the current-voltage relationship (I-V) was …

Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis

D Engblom, S Saha, L Engström, M Westman… - Nature …, 2003 - nature.com
We studied the febrile response in mice deficient in microsomal prostaglandin E synthase-1
(mPGES-1), an inducible terminal isomerase expressed in cytokine-sensitive brain …

[PDF][PDF] Glutamate receptors on dopamine neurons control the persistence of cocaine seeking

D Engblom, A Bilbao, C Sanchis-Segura, L Dahan… - Neuron, 2008 - cell.com
… (D–I) Representative coronal sections from the VTA showing immunofluorescence for GluR1
(D and G) and TH (E and H) in control (D–F) and GluR1DATCre (G–I) mice, respectively. In …

[HTML][HTML] Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting

M Hagbom, C Istrate, D Engblom, T Karlsson… - PLoS …, 2011 - journals.plos.org
… (A–D) Sections of paraffin-embedded small intestine tissue from uninfected BALB/c mice
were … (C, D) Sections of jejunum intestinal tissue were stained for RV (red) and 5-HT (green). …

[HTML][HTML] Hippocampal function is impaired by a short-term high-fat diet in mice: Increased blood–brain barrier permeability and neuroinflammation as triggering events

…, JM Gaspar, LA Velloso, D Engblom… - Frontiers in …, 2021 - frontiersin.org
… (D) Sodium fluorescein assay to evaluate BBB permeability on hippocampus (n = 5–7; t-test
for 1, 2, and 4 weeks of diet). Values are mean ± SEM. + Means higher than the hypothetical …

Chest pain and ischaemic heart disease in primary care.

S Nilsson, M Scheike, D Engblom, LG Karlsson… - British Journal of …, 2003 - bjgp.org
BACKGROUND: Chest pain is the main symptom of first presentation with ischaemic heart
disease (IHD). Little is known about the incidence of IHD among patients consulting the …