Aims Stimulant use disorder contributes to a substantial worldwide burden of disease, although
evidence-based treatment options are limited. This systematic review of reviews aims to: (…

… in concurrent problem alcohol and illicit drug users - Klimas, J - 2018 | Cochrane Library …
of Feldman 2013, a paper we included in the first version of this review (Klimas 2012a). …

… Author Contributions: Dr Klimas had full access to all of the data in the study and takes …
Conflict of Interest Disclosures: Dr Klimas reported grants from the European Commission outside …

… Author links open overlay panel Jana Kmecova a b , Jan Klimas a … , one group of rats was
measured using both 12-lead ECG and orthogonal Frank ECG, as well (Klimas et al., 2008). …

Aims The role of nitric oxide (NO) in heart failure (HF) is complex and remains controversial.
We tested the hypothesis that the role of NO in isolated atria and cardiomyocytes is altered …

Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal
Mas receptor in spontaneously hypertensive rats - Klimas - 2015 - Journal of Cellular and …

Importance Although severe alcohol withdrawal syndrome (SAWS) is associated with substantial
morbidity and mortality, most at-risk patients will not develop this syndrome. Predicting …

Caffeine is a most widely consumed physiological stimulant worldwide, which is consumed
via natural sources, such as coffee and tea, and now marketed sources such as energy …

Background Although oral opioid agonist therapies (OATs), buprenorphine and methadone,
are effective first-line treatments, OAT remains largely underutilized due to low retention …

Canada and the United States (US) face an opioid use disorder (OUD) and opioid overdose
epidemic. The most effective OUD treatment is opioid agonist therapy (OAT)—…