In many organisms the allocation of primordial germ cells (PGCs) is determined by the
inheritance of maternal factors deposited in the egg. However, in mammals, inductive cell …

Mesodermal signaling is critical for patterning the embryonic endoderm into different tissue
domains. Classical tissue transplant experiments in the chick and recent studies in the …

… Ray Dunn and BLMH, unpublished observations). We have previously reported expression
of Bmp4 lacZ in both lung endoderm and mesenchyme (Weaver et al., 1999). Removal of the …

Transplantation of human embryonic stem cells (hESC) into immune-deficient mice leads to
the formation of differentiated tumors comprising all three germ layers, resembling …

The Smad proteins are important intracellular mediators of the transforming growth factor β (TGFβ)
family of secreted growth factors. Smad1 is an effector of signals provided by the bone …

It is well known that cell fate decisions in the mouse organizer region during gastrulation
ultimately govern gut formation and patterning, left–right axis determination, and development …

Blimp1, a zinc-finger containing DNA-binding transcriptional repressor,functions as a master
regulator of B cell terminal differentiation. Considerable evidence suggests that Blimp1 is …

Understanding the molecular mechanisms controlling early cell fate decisions in mammals
is a major objective toward the development of robust methods for the differentiation of …

In the mature mouse lung, the proximal-distal (PD) axis is delineated by two distinct epithelial
subpopulations: the proximal bronchiolar epithelium and the distal respiratory epithelium. …

BACKGROUND: As a consequence of the greater use of agents affecting the serotonergic
system, a syndrome of serotonin hyperstimulation has been recognized more frequently. The …