Cyclonic storms associated with the midlatitude Subtropical Westerly Jet (SWJ), referred to
as Western Disturbances (WDs), play a critical role in the meteorology of the Indian …

Many normal cells respond to potentially oncogenic stimuli by undergoing cellular senescence,
a state of irreversibly arrested proliferation and altered differentiated function. Cellular …

Most normal human cells undergo cellular senescence after accruing a fixed number of cell
divisions, or are challenged by a variety of potentially oncogenic stimuli, in culture and most …

Normal somatic cells invariably enter a state of irreversibly arrested growth and altered function
after a finite number of divisions. This process, termed replicative senescence, is thought …

On 7 February 2021, a catastrophic mass flow descended the Ronti Gad, Rishiganga, and
Dhauliganga valleys in Chamoli, Uttarakhand, India, causing widespread devastation and …

The polycomb protein Bmi-1 represses the INK4a locus, which encodes the tumor suppressors
p16 and p14 ARF . Here we report that Bmi-1 is downregulated when WI-38 human …

Normal cells do not divide indefinitely due to a process known as replicative senescence.
Human cells arrest growth with a senescent phenotype when they acquire one or more …

The vast majority of breast cancers are carcinomas that arise from mammary epithelial cells (MECs).
One of the key early events in tumorigenic transformation is the ability of cells to …

Telomere erosion is considered to be the main cause of the onset of replicative senescence.
However, recent findings suggest that a senescent phenotype can be induced by a variety …

The Bmi-1 oncoprotein regulates proliferation and oncogenesis in human cells. Its
overexpression leads to senescence bypass in human fibroblasts and immortalization of human …