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Clinical Work in General Practice

Trimethoprim and co-trimoxazole in the treatment of acute urinary tract infections: patient compliance and efficacy

D. A. Andrewes, P. J. Chuter, M. J. Dawson, B. W. Eden, R. M. A. Moore, D. S. Freestone and C. A. Morris
The Journal of the Royal College of General Practitioners 1981; 31 (226): 274-280.
D. A. Andrewes
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P. J. Chuter
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M. J. Dawson
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B. W. Eden
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R. M. A. Moore
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D. S. Freestone
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C. A. Morris
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Abstract

Patient compliance and drug efficacy and side-effects were compared in two groups of patients with symptoms of acute lower urinary tract infections. One group was treated with trimethoprim, one tablet (300 mg) once a day, and the other with co-trimoxazole, two tablets (160 mg trimethoprim, 800 mg sulphamethoxazole) twice a day; both treatments were prescribed for seven days. Patient compliance was significantly greater with trimethoprim: corrected percentage compliance rates were 97·5 per cent for trimethoprim and 79·1 per cent for co-trimoxazole (p<0·05). Trimethoprim and co-trimoxazole were of equivalent effectiveness in the control of symptoms. Side-effects were more frequent with co-trimoxazole, but the difference was not significant.

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The Journal of the Royal College of General Practitioners: 31 (226)
The Journal of the Royal College of General Practitioners
Vol. 31, Issue 226
May 1981
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Trimethoprim and co-trimoxazole in the treatment of acute urinary tract infections: patient compliance and efficacy
D. A. Andrewes, P. J. Chuter, M. J. Dawson, B. W. Eden, R. M. A. Moore, D. S. Freestone, C. A. Morris
The Journal of the Royal College of General Practitioners 1981; 31 (226): 274-280.

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Trimethoprim and co-trimoxazole in the treatment of acute urinary tract infections: patient compliance and efficacy
D. A. Andrewes, P. J. Chuter, M. J. Dawson, B. W. Eden, R. M. A. Moore, D. S. Freestone, C. A. Morris
The Journal of the Royal College of General Practitioners 1981; 31 (226): 274-280.
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Print ISSN: 0960-1643
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