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Intended for Healthcare Professionals
British Journal of General Practice

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Original Papers

Double-blind placebo-controlled trial of amitriptyline among depressed patients in general practice

Julie A. Hollyman, P. Freeling, E.S. Paykel, A. Bhat and P. Sedgwick
The Journal of the Royal College of General Practitioners 1988; 38 (314): 393-397.
Julie A. Hollyman
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P. Freeling
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E.S. Paykel
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A. Bhat
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P. Sedgwick
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Abstract

Depressed patients in general practice were included in a double-blind placebo-controlled six-week trial of amitriptyline (median dose 125 mg). The patients were relatively mildly ill and satisfied diagnostic criteria for depression and treatment with antidepressants in routine practice. Amitriptyline was found to be considerably superior to placebo after six weeks and significantly so as early as two weeks after the start of treatment. The effects of the antidepressant were on the core symptoms of depression, and were apparent in all but the most mildly ill patients. The findings suggest that tricyclic antidepressants are of considerable therapeutic benefit to depressed patients in general practice.

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The Journal of the Royal College of General Practitioners: 38 (314)
The Journal of the Royal College of General Practitioners
Vol. 38, Issue 314
September 1988
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Double-blind placebo-controlled trial of amitriptyline among depressed patients in general practice
Julie A. Hollyman, P. Freeling, E.S. Paykel, A. Bhat, P. Sedgwick
The Journal of the Royal College of General Practitioners 1988; 38 (314): 393-397.

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Double-blind placebo-controlled trial of amitriptyline among depressed patients in general practice
Julie A. Hollyman, P. Freeling, E.S. Paykel, A. Bhat, P. Sedgwick
The Journal of the Royal College of General Practitioners 1988; 38 (314): 393-397.
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Print ISSN: 0960-1643
Online ISSN: 1478-5242