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Research Article

Megatrials are based on a methodological mistake.

B G Charlton
British Journal of General Practice 1996; 46 (408): 429-431.
B G Charlton
Department of Psychology, University of Newcastle upon Tyne.
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Abstract

Despite their prestige, megatrials are founded upon a methodological error. This is the assumption that randomization of very large numbers of subjects can compensate for deliberately reduced levels of experimental control, but there is no trade-off between size and rigour. Randomized trials are not a 'gold standard' because no method is intrinsically valid-there are good and bad trials. Interpretation of megatrials is always difficult and requires considerable clinical and scientific knowledge. Three fundamental parameters should be considered when evaluating the applicability of a trial to clinical practice: rigour of design; representativeness of the trial population; and homogeneity of the recruited subjects.

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British Journal of General Practice: 46 (408)
British Journal of General Practice
Vol. 46, Issue 408
July 1996
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Megatrials are based on a methodological mistake.
B G Charlton
British Journal of General Practice 1996; 46 (408): 429-431.

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Megatrials are based on a methodological mistake.
B G Charlton
British Journal of General Practice 1996; 46 (408): 429-431.
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Print ISSN: 0960-1643
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