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Research Article

Antibiotic treatment of acute otitis media in children under two years of age: evidence based?

R A Damoiseaux, F A van Balen, A W Hoes and R A de Melker
British Journal of General Practice 1998; 48 (437): 1861-1864.
R A Damoiseaux
Department of General Practice, Utrecht University, The Netherlands.
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F A van Balen
Department of General Practice, Utrecht University, The Netherlands.
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A W Hoes
Department of General Practice, Utrecht University, The Netherlands.
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R A de Melker
Department of General Practice, Utrecht University, The Netherlands.
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Abstract

BACKGROUND: Appropriate use of antibiotics is one of the major issues in medicine today. In most countries, acute otitis media in children is treated with antibiotics; however, the efficacy of antibiotic use in every acute otitis media is a controversial issue. It may be worthwhile looking for special risk groups that benefit more from antibiotic treatment for acute otitis media. Children under two years of age with acute otitis media are at risk of poor outcome. AIM: To assess whether the current high prescription rates of antibiotics for acute otitis media in children under two years of age (being a risk group for poor outcome) are based on an established increased efficacy. METHOD: Systematic literature review and a quantitative analysis with an assessment of the methodological quality of published trials, comparing antibiotic treatment with non-antibiotic treatment in acute otitis media in children aged under two years. RESULTS: Six trials were included. Trials from before 1981 had a poor methodological quality. Four were suitable for the quantitative analysis. Only two of them were truly placebo-controlled. Of these two, one included only recurrent acute otitis media and the other included only non-severe episodes. With these restricted data, no statistically significant difference was found between antibiotic-treated children and controls under two years of age with acute otitis media, judged on the basis of clinical improvement within seven days (common odds ratio = 1.31; 95% CI = 0.83-2.08). CONCLUSION: The current high prescription rates of antibiotics among children under two years of age with acute otitis media are not sufficiently supported by evidence from published trials. New randomized placebo-controlled trials using reliable methodology are needed in this young age group.

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British Journal of General Practice: 48 (437)
British Journal of General Practice
Vol. 48, Issue 437
December 1998
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Antibiotic treatment of acute otitis media in children under two years of age: evidence based?
R A Damoiseaux, F A van Balen, A W Hoes, R A de Melker
British Journal of General Practice 1998; 48 (437): 1861-1864.

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Antibiotic treatment of acute otitis media in children under two years of age: evidence based?
R A Damoiseaux, F A van Balen, A W Hoes, R A de Melker
British Journal of General Practice 1998; 48 (437): 1861-1864.
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Print ISSN: 0960-1643
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