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Intended for Healthcare Professionals
British Journal of General Practice

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Research Article

Improving the ascertainment of families at high risk of colorectal cancer: a prospective GP register study.

Peter W Rose, Michael Murphy, Marcus Munafo, Cyril Chapman, Neil Mortensen and Anneke Lucassen
British Journal of General Practice 2004; 54 (501): 267-271.
Peter W Rose
Department of Primary Health Care, Institute of Health Sciences, University of Oxford, Old Road, Headington, Oxford OX3 7LF, UK. peter.rose@dphpc.ox.ac.uk
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Michael Murphy
Department of Primary Health Care, Institute of Health Sciences, University of Oxford, Old Road, Headington, Oxford OX3 7LF, UK. peter.rose@dphpc.ox.ac.uk
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Marcus Munafo
Department of Primary Health Care, Institute of Health Sciences, University of Oxford, Old Road, Headington, Oxford OX3 7LF, UK. peter.rose@dphpc.ox.ac.uk
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Cyril Chapman
Department of Primary Health Care, Institute of Health Sciences, University of Oxford, Old Road, Headington, Oxford OX3 7LF, UK. peter.rose@dphpc.ox.ac.uk
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Neil Mortensen
Department of Primary Health Care, Institute of Health Sciences, University of Oxford, Old Road, Headington, Oxford OX3 7LF, UK. peter.rose@dphpc.ox.ac.uk
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Anneke Lucassen
Department of Primary Health Care, Institute of Health Sciences, University of Oxford, Old Road, Headington, Oxford OX3 7LF, UK. peter.rose@dphpc.ox.ac.uk
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Abstract

BACKGROUND: Screening for colorectal cancer is effective in family members with a high risk of this condition, owing to single gene mutations. However, it is not known which is the most effective method of ascertaining these families at high risk. AIMS: To investigate whether a case-finding approach using computerised general practitioner (GP) registers would improve the ascertainment of families at high risk of colorectal cancer due to family history. DESIGN OF STUDY: Prospective GP register study. SETTING: General practices in Oxfordshire. METHOD: Identification of patients with colorectal cancer using GP registers, followed by a family history questionnaire survey to identify those at high risk. RESULTS: Using GP registers, 758 patients with a diagnosis of colorectal cancer were identified; a prevalence of 172 cases per 100 000 (95% confidence interval = 159 to 184). Of these, 305 patients, diagnosed under the age of 65 years, were sent a family history questionnaire. Two hundred and one (66%) patients responded to the survey; 10 (5%) patients were assessed as having high-risk families and 47 (23%) patients were assessed as having families at moderate risk. Eight of the high-risk patients had 34 first degree relatives who would benefit from routine disease surveillance, and 37 moderate-risk patients had 153 first degree relatives. Only two high-risk and six moderate-risk patients identified were previously known to the local Clinical Genetics Department. CONCLUSION: A case-finding approach using GP records and a family history questionnaire is an effective way of identifying families at high risk of developing colorectal cancer, who can then be offered disease surveillance.

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British Journal of General Practice: 54 (501)
British Journal of General Practice
Vol. 54, Issue 501
April 2004
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Improving the ascertainment of families at high risk of colorectal cancer: a prospective GP register study.
Peter W Rose, Michael Murphy, Marcus Munafo, Cyril Chapman, Neil Mortensen, Anneke Lucassen
British Journal of General Practice 2004; 54 (501): 267-271.

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Improving the ascertainment of families at high risk of colorectal cancer: a prospective GP register study.
Peter W Rose, Michael Murphy, Marcus Munafo, Cyril Chapman, Neil Mortensen, Anneke Lucassen
British Journal of General Practice 2004; 54 (501): 267-271.
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