New Eng J Med Vol 351
543 The modern management of heart failure consists largely of blocking the renin-angiotensin-aldosterone system comprehensively, and the RALES trial showed that adding spironolactone to existing treatment improved survival by nearly 30%. Only, try not to kill the patient with hyperkalaemia — it didn't happen in the trial, but happened rather often when keen GPs in Ontario adopted the new treatment without due caution.
637 Are you a smart defibrillator? If you are trained to use the machine, you might by remote chance save somebody with out-of-hospital cardiac arrest — 19 000 American volunteers just reached statistical significance. Training them in advanced life support brought no further benefit.
681 A brisk US review of generalised anxiety disorder tells you to prescribe serotonin reuptake inhibitors and benzodiazepines and cognitive behavioural therapy — more like British general practice than Frasier.
868 Surprisingly, children who have to take high-dose steroids …