Overall change (P-valuea) | 5.6 (<0.001) | 4.2 (<0.001) | 3.0 (0.003) | 2.7 (0.007) | 1.7 (0.08) | 3.1 (0.002) | 3.5 (<0.001) | 3.8 (<0.001) | 4.8 (<0.001) |
|
Change at 3 months mean (SE) | 5.7 (3.2) | 13.4 (3.3) | 1.9 (2.6) | 9.1 (2.1) | 1.6 (3.3) | 9.0 (3.0) | 3.3 (3.1) | 7.2 (3.2) | −0.4 (4.2) | 10.2 (3.3) | 6.0 (4.5) | 6.6 (3.3) | −0.5 (4.0) | 10.2 (4.7) | 9.2 (3.8) | 8.7 (3.3) | 3.9 (2.6) | 10.1 (2.8) |
|
t (P-valuea) | 1.9 (0.06) | 1.8 (0.07) | 1.6 (0.12) | 0.5 (0.61) | 1.5 (0.14) | 0.2 (0.81) | 1.8 (0.07) | 0.3 (0.75) | 1.6 (0.11) |
|
Change at 12 months mean (SE) | 12.8 (4.6) | 18.6 (3.5) | 8.8 (4.7) | 12.0 (2.8) | 3.7 (5.4) | 9.7 (3.3) | 9.1 (4.3) | 10.1 (3.9) | 9.8 (7.0) | 8.6 (4.6) | 9.4 (4.7) | 10.5 (3.0) | 5.6 (5.2) | 13.5 (6.1) | 11.7 (4.5) | 11.2 (2.7) | 10.9 (4.3) | 13.6 (3.0) |
|
t (P-valuea) | 1.2 (0.25) | 1.1 (0.28) | 1.7 (0.09) | 0.7 (0.47) | 0.4 (0.70) | 0.8 (0.41) | 1.6 (0.11) | 0.8 (0.43) | 1.2 (0.24) |