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British Journal of General Practice

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Original Papers

Use of antibiotics for sore throat and incidence of quinsy

Nick Dunn, Dan Lane, Hazel Everitt and Paul Little
British Journal of General Practice 2007; 57 (534): 45-49.
Nick Dunn
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Dan Lane
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Hazel Everitt
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Paul Little
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Abstract

Background Quinsy is the most common major suppurative complication of sore throat. Evidence on the effectiveness of antibiotics in preventing quinsy is sparse.

Aim To assess the incidence of quinsy and the pattern of presentation, and to identify variables that predict the development of quinsy.

Design of study Case-control study.

Setting UK-wide primary care.

Method Retrospective analysis of data from the General Practice Research Database (GPRD) for the years 1995–1997.

Results There were 606 recorded cases of patients with quinsy, but only 192 (31%) of these patients presented following an initially uncomplicated sore throat. Patients with quinsy were more likely to be aged 21–40 years (odds ratio [OR] = 2.5, 95% confidence interval [CI] = 1.7 to 3.6, compared with other ages), smokers (OR = 2.5, 95% CI = 1.8 to 3.5), and male (OR = 1.6, 95% CI = 1.1 to 2.2). Quinsy developed very quickly for most patients (median of 2 days after tonsillitis and 3 days after a sore throat). For cases initially labelled as tonsillitis, there was a non-significant trend of antibiotics preventing quinsy (OR = 0.6, 95% CI = 0.3 to 1.3), but no evidence that antibiotics prevent quinsy for cases labelled as sore throat or pharyngitis (OR = 1.2, 95% CI = 0.7 to 2.2).

Conclusion Most patients with quinsy develop the condition rapidly, and many do not present with a respiratory tract infection to their GP first. The current low doses of antibiotics used in modern community settings may be less likely to protect against quinsy than the trial evidence suggests.

  • antibiotics
  • incidence
  • quinsy
  • sore throat
  • Received April 11, 2006.
  • Revision received June 8, 2006.
  • Accepted July 18, 2006.
  • © British Journal of General Practice, 2007.
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British Journal of General Practice: 57 (534)
British Journal of General Practice
Vol. 57, Issue 534
January 2007
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Use of antibiotics for sore throat and incidence of quinsy
Nick Dunn, Dan Lane, Hazel Everitt, Paul Little
British Journal of General Practice 2007; 57 (534): 45-49.

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Use of antibiotics for sore throat and incidence of quinsy
Nick Dunn, Dan Lane, Hazel Everitt, Paul Little
British Journal of General Practice 2007; 57 (534): 45-49.
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Keywords

  • antibiotics
  • incidence
  • quinsy
  • sore throat

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Print ISSN: 0960-1643
Online ISSN: 1478-5242