• Proton pump inhibitor with atazanavir or rilpivirine | • Significant reduction in AUCb of atazanavir and rilpivirine | • If acid suppression needed discuss with patient and specialist |
• Simvastatin with boosted protease inhibitors | • Significantly increased blood concentration of simvastatin leading to toxicity: potential myopathy and rhabdomyolysis | • Preferential use of atorvastatin (<20 mg initially) with all ART |
• Inhaled or intranasal mometasone/fluticasone/budesonide with boosted protease inhibitors | • Increased blood levels of steroid and associated risk of systemic glucocorticoid effects | • Discuss with patient and specialist to decide on how to safely switch to beclomethasone |