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- Page navigation anchor for The chronotherapy of hypertension: or the benefit of taking blood pressure tablets at bedtimeThe chronotherapy of hypertension: or the benefit of taking blood pressure tablets at bedtimeWe read with interest the article in Issue 657 about chronotherapy in hypertension.1 The author states "There is clearly scope to repeat a trial similar to MAPEC in a UK general practice population”. We would like to point out that such a trial is already underway in the UK, led by the Medicines Monitoring Unit (MEMO) in Dundee.The Treatment in Morning versus Evening (TIME) study, has been running since 2011. The full project, funded by the British Heart Foundation, began in 2014. We have 21,115 participants randomised to either morning or evening administration of their usual antihypertensives. The study (www.timestudy.co.uk) is conducted using an online methodology. Participants are all aged 18 or over, registered with a UK GP, and taking at least one antihypertensive medication. They are followed-up by automated email and asked to submit follow-up data online. This information includes adherence to assigned dosing time, participant-reported outcomes including cardiovascular events and falls, and other perceived adverse effects of dosing time. This participant derived information will augment record linkage to national databases to identifying the primary study outcomes of non-fatal MI, non-fatal stroke, or vascular death. TIME also includes three sub-studies investigating cognitive function, sleep quality and home blood pressure measurements. We expect that this event-driven study will complete towards the end of 2...Show MoreCompeting Interests: The TIME study is funded by the British Heart Foundation and supported by the British and Irish Hypertension Society, the Scottish Primary Care Research Network and the NIHR Clinical Research Network.