Is primary care research important and relevant to GPs?

IMPORTANCE AND DOMINANCE OF BASIC SCIENCE MEDICAL RESEARCH

Most biomedical research has historically been centred on basic science and the pursuit of discovery, for example, on the mechanisms of disease and their amelioration. Until latterly, the application of this science was seen merely as a professional responsibility — why don’t practitioners just get on and apply the important findings? But such implementation delays may be more to do with incomplete evidence than clinical inertia, hence one argument for more applied research evidence to inform discovery science.

A century of serial multi-billion-dollar investments in basic and discovery science generated the interventions we use today. But this investment is being challenged by the dawning recognition by health systems that they need a better evidence base to inform the structure and provision of care, and how to apply the findings of much of this extraordinary biomedical science. Despite basic research consuming most of the global health research investment, much of health care remains empirical and non-evidence based. And, even when evidence gives a clear directive on what to do, slow translation into clinical practice may be as often due to uncertainties as to how to apply the data than on professional inertia.

Belated recognition of such barriers to implementation has led to the introduction of a more applied clinical research focus in many countries with developed healthcare systems, such as the NHS, that complements basic science and discovery research. First came the science around evidence-based medicine (EBM), for 20 years developing and employing better methods of synthesising and presenting the totality of quality evidence and thereby reducing uncertainty. Latterly an investment in applied health research, and the capacity to better deliver this, has gathered impetus internationally, for example, via the main driver for such applied research in the UK, the National Institute for Health Research (NIHR).

Primary care and primary care academics have steadily contributed to many aspects of health research, but it has been particularly important in applied research at the structural and inspirational levels.

DO WE NEED PRIMARY CARE RESEARCH?

But, is research based within primary care important? Given that most patient contacts originate and end in primary care in most developed health systems, the necessity to research more within primary care is obvious. The full spectrum of disease is represented, the long trajectory of disease is discoverable, and the patient subjects are representative of the total population and demonstrate the full range of behaviours. The traditional model of researching more extreme phenotypes, represented in hospital-recruited cohorts, remains important, and efficient, for early research and estimating the likely best effects of interventions, partly because patients triaged to hospital will mostly experience higher and earlier event rates. Care in specialist settings also needs to be based on research conducted in specialist settings. However, the corollary should be self-evident — care in the community should be based on evidence from community populations, whether for diagnostic test performance and thresholds or for therapeutic interventions.

Failure to provide such ‘context’ evidence has historically contributed to confusion and delay in applying promising evidence to the clinical care of the masses, hence ‘my patients aren’t like those included in that trial’. Such protestations should diminish with applied research refining answers to ‘what to do’ with showing ‘how to do it’.

One important rider to evidence-based practice is the risk of nihilism — science is provisional and rarely absolute, and we can’t wait indefinitely before acting. Until we have entirely predictable personalised medicine (a generation off, if ever), mostly we will have to apply best evidence to the population and accept that some may not benefit or may even be harmed. Patients, I think, understand these realities better than physicians do sometimes and deserve neutral presentation of uncertainty, even when they respond by saying, ‘But what would you do, doctor?’ There is, of course, also the important risk of over-diagnosis and over-treatment, more prominently highlighted than clinical inertia, which mandates ensuring that the limitations of data are recognised.

Health science therefore needs evidence derived from the populations in which that evidence is to be applied, so that research in primary care is scientifically essential. There are also some important practical benefits of such an approach: it is increasingly difficult to recruit to landmark trials, especially with active comparators, without recruiting in primary care, and doctors involved in research are more likely early adopters of technologies found to be effective — an efficient implementation strategy.

HISTORIC CONTRIBUTIONS OF PRIMARY CARE ACADEMICS TO CLINICAL SCIENCE

Yet, having argued that research based in primary care is important, whether we need primary care academics to conceptualise and deliver some of this research deserves answering. The influence of primary care researchers is not a modern phenomenon. The origins of high-quality clinical research had primary care champions: Edward Jenner, who in the 18^th century observed associations with smallpox and trialled a candidate cowpox vaccine, thus founding the science of immunisation, was a West Country family doctor; John Snow, a mid-19^th-century founding father of epidemiology, was also a family doctor.

Thirty years ago, important research by academic GPs explained what makes better consultations¹ and provided observations on the inadequacies of health care² that helped spawn EBM.³ Primary care researchers, clinical and methodological, are strongly represented in advancing EBM internationally and have become essential contributors to more reliable methods of generating evidence-based guidelines,⁴ a key mechanism used by health systems to define the expected standards of care expected of practitioners working in the system.

RECENT CONTRIBUTIONS OF PRIMARY CARE ACADEMICS TO CLINICAL SCIENCE

The impact of primary care academics has accelerated in the past 20 years, and across many major clinical areas. There is notable health services research on surrogate measures for quality of care, evidence on whether pay for performance works,⁵ and even what happens when incentives stop,⁶ all providing key evidence for more evidence-based policy development. A major current deficit in most health systems is trial-and-error planning — risky and expensive given it is difficult to de-commission services once they are provided to the public.

In terms of evidence for clinical practice there are major advances in utilising diagnostics more effectively and safely in primary care, providing the key missing data for better implementation of evidence from specialist settings, such as the necessary performance of validated disease risk scores;⁷ the most cost-effective methods of diagnosing and then managing hypertension;⁸ and thresholds for biomarkers, such as natriuretic peptides in symptomatic patients,⁹ all helping to triage at-risk populations more efficiently. Such primary care researchers, in partnership with the practices or primary care research networks that conduct the research, are also contributing to the evidence for screening or early detection of major impact disorders, such as diabetes,¹⁰ atrial fibrillation,¹¹ and heart failure.

In clinical management, in addition to major work in major long-term disorders, primary care academics have made major contributions to infection research including antibiotic conservation,¹² and to acute problems such as Bell’s palsy.¹³ The long-term primary care interest in health services research has continued, but with higher-quality study designs, reporting on what makes more effective consultations, or how to configure primary care,¹⁴ or focus on major social issues.

A tradition of primary care academics in public health research has also continued, for example, highlighting the emerging importance of multimorbidity in our increasingly ageing populations,¹⁵ with the ongoing challenges of determining the most impactful disease combinations and predicting the most adverse pathways for testing interventional strategies. It is possible that deep genotypic categorisation may ultimately predict personal health trajectories, but there will be decades of needing better phenotyping and predictive models.

In conclusion, the importance and practice relevance of more research based in primary care is clear, as is the essential role for academic primary care and its partnerships with practices. Primary care evidence has regularly impacted on informing international clinical guidelines, which is itself a useful surrogate for relevance and impact. The rate of such research has accelerated in the past 20 years and the quality and complexity has increased. Health systems should highlight the importance of primary care research to help deliver and guide priorities, and invest in the academics and research practice networks that provide the evidence.