Sudden-onset dizziness and vertigo symptoms: assessment and management of vestibular causes

Vestibular migraine

VM is a variant of migraine and has a prevalence of approximately 1% of the population.² It is emerging as a clinical entity with publication of diagnostic criteria in 2012 inclusive of a category for probable VM.⁴ The diagnostic criteria comprise vestibular symptoms for up to 72 hours, known or current history of migraine (not essential for diagnosis), presence of a characteristic headache, photo/phonophobia, or aura symptoms. Triggers include stress, tiredness, skipping meals, certain food groups, and menstruation. Avoidance of triggers and lifestyle changes improve many patients’ symptoms. Cases persisting despite trigger avoidance and lifestyle changes can be commenced on prophylactic migraine medications.

Vestibular neuritis

This condition classically causes debilitating sudden vertigo often following a viral upper respiratory tract infection. It is thought to be due to viruses affecting the superior vestibular nerve in its narrow bony canal. VN is also sometimes incorrectly referred to as labyrinthitis — labyrinthitis by definition involves a loss of hearing as well.

The HINTS examination (Supplementary Table 2) can be used to differentiate this from acute cerebellar strokes.

Supportive treatments are offered including short-term anti-emetics (long-term vestibular sedatives delay compensation). Physical activity is encouraged where possible to aid vestibular compensation and expedite recovery times. There is a potential role for systemic steroids, although a Cochrane review in 2011 determined there was insufficient evidence for usage.⁵

Most patients have an uneventful recovery within weeks, although a small proportion develop secondary BPPV, chronic imbalance caused by the resulting vestibulopathy, over-reliance on visual stimuli, or neuropsychological sequelae such as persistent postural-perceptual dizziness (PPPD).

Benign paroxysmal positional vertigo

BPPV has a prevalence of approximately 1–2% of the population.² It is caused by displacement of otoconia from the utricle, most commonly into the posterior semicircular canal (canalithiasis). The history is typically short spins exacerbated by head movements, particularly rolling over in bed or looking up. There may be a history of previous head trauma or recent VN. BPPV is supported by a positive Dix–Hallpike test or reproducible symptoms in the Dix–Hallpike position if no nystagmus is seen. This can be followed by an Epley manoeuvre with advice to sleep propped up for a few days thereafter. Brandt–Daroff exercise can be performed by the patient if symptoms recur.

Resistant cases may be due to cupulolithiasis (otoconia adherent to the cupula) and the Semont manoeuvre can be helpful. Acute worsening of dizziness immediately after an Epley may be caused by octoconia diverted into the lateral semicircular canal. A log roll manoeuvre (‘BBQ roll’) is adopted in these patients.

Surgery to the posterior semi-circular canal is performed in a tiny cohort of patients with intractable recurrent symptoms despite repositioning manoeuvres.

Ménière’s disease

The prevalence of Ménière’s disease is approximately 1 in 1000 of the population.² Vertigo typically lasts from 20 minutes to 12 hours with patients also reporting tinnitus, aural fullness, and fluctuating hearing loss. The hearing loss often recovers between attacks in the early stages of the disease but eventually becomes permanent. Drop attacks occur infrequently, late in the disease.

The underlying histopathological marker is endolymphatic hydrops.

Treatments can include dietary and lifestyle changes (salt and caffeine reduction), betahistine, bendroflumethiazide, topical agents delivered via the middle ear (such as steroids and gentamicin), and very rarely surgery on the labyrinth. Intra-tympanic steroids have been shown to lead to an average 90% reduction in vertigo over 2 years⁶ and are now a mainstay of therapy. Dietary advice and betahistine are commonly commenced in general practice with further treatments recommended by an otolaryngologist. However, it should be noted that a BMJ publication in 2016⁷ showed no reduction in vertigo over placebo with betahistine, and this should be discussed with patients before prescription. It has some vestibular sedative action.

There is diagnostic overlap with vestibular migraine. Diagnostic criteria for Ménière’s were published in 2015.⁸ Ménière’s is classified into definite and probable categories; the latter patients do not demonstrate audiometric evidence of hearing loss. Other diagnostic criteria include two or more vertiginous episodes lasting up to 12 hours and fluctuating aural symptoms (tinnitus, aural fullness, and deafness). Patients can be asymptomatic between episodes early in the disease.