1. Beta-blocker | Bisoprolol 2.5 mg o.d. | 3–4 | Bisoprolol 10 mg o.d. |
Carvedilol 3.125 mg b.d. | | Carvedilol 25–50 mg b.d. |
|
2. ACEI or ARB or ARNIb | Ramipril 2.5 mg o.d. | 3–4 | Ramipril 10 mg o.d. |
Perindopril erbumine 2 mg o.d. | | Perindopril erbumine 4–8 mg o.d. |
Lisinopril 2.5 mg o.d. | | Lisinopril 35 mg o.d. |
|
Losartan 12.5 mg o.d. | 4 | Losartan 150 mg o.d. |
Valsartan 40 mg b.d. | | Valsartan 160 mg b.d. |
Candesartan 4 mg o.d. | | Candesartan 32 mg o.d. |
|
Sacubitril–valsartan 48/52 mg b.d., or 24/26 mg b.d. if BP low | 1–2 | 97/103 mg b.d. |
|
3. MRA | Spironolactone 25 mg o.d. | 2–3 | Spironolactone 50 mg o.d. |
Eplerenone 25 mg o.d. | | Eplerenone 50 mg o.d. |
|
4. SGLT2i | Dapagliflozin 10 mg o.d. | 0 | Dapagliflozin 10 mg o.d. |