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Research

Nortriptyline for pain in knee osteoarthritis: a double-blind randomised controlled trial in New Zealand general practice

Ben Hudson, Jonathan A Williman, Lisa K Stamp, John S Alchin, Gary J Hooper, Dee Mangin, Bronwyn F Lenox Thompson and Les Toop
British Journal of General Practice 2021; 71 (708): e538-e546. DOI: https://doi.org/10.3399/BJGP.2020.0797
Ben Hudson
Department of General Practice, University of Otago, Christchurch.
Roles: Senior lecturer
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Jonathan A Williman
Biostatistics and Computational Biology Unit, University of Otago, Christchurch.
Roles: Research fellow
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Lisa K Stamp
Department of Medicine, University of Otago; Canterbury District Health Board, Christchurch.
Roles: Professor
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John S Alchin
Pain Management Centre, Canterbury District Health Board, Christchurch, New Zealand.
Roles: Consultant
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Gary J Hooper
Department of Orthopaedic Surgery and Musculoskeletal Medicine, University of Otago; Canterbury District Health Board, Christchurch.
Roles: Professor
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Dee Mangin
Department of General Practice, University of Otago, Christchurch.
Roles: Professor
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Bronwyn F Lenox Thompson
Department of Orthopaedic Surgery and Musculoskeletal Medicine, University of Otago, Christchurch.
Roles: Clinical senior lecturer
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Les Toop
Department of General Practice, University of Otago, Christchurch.
Roles: Professor
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Jump to comment:

  • Result of primary outcome
    Shu Yun Tan
    Published on: 24 November 2022
  • Published on: (24 November 2022)
    Page navigation anchor for Result of primary outcome
    Result of primary outcome
    • Shu Yun Tan, GP, National Healthcare Group Polyclinics Singapore

    Dear Authors

    I am writing to clarify about the primary outcome reported in the study.

    Efficacy (e541)
    Primary Outcome: On average, participants were given nortriptyline had a WOMAC pain subscale score at week 14 that was 6.2 points lower (95% CI = -0.26 to 12.56)

    May I ask if the 95% CI reported is corrected as the score of -6.2 is not within the 95% CI.

    Competing Interests: None declared.
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British Journal of General Practice: 71 (708)
British Journal of General Practice
Vol. 71, Issue 708
July 2021
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Nortriptyline for pain in knee osteoarthritis: a double-blind randomised controlled trial in New Zealand general practice
Ben Hudson, Jonathan A Williman, Lisa K Stamp, John S Alchin, Gary J Hooper, Dee Mangin, Bronwyn F Lenox Thompson, Les Toop
British Journal of General Practice 2021; 71 (708): e538-e546. DOI: 10.3399/BJGP.2020.0797

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Nortriptyline for pain in knee osteoarthritis: a double-blind randomised controlled trial in New Zealand general practice
Ben Hudson, Jonathan A Williman, Lisa K Stamp, John S Alchin, Gary J Hooper, Dee Mangin, Bronwyn F Lenox Thompson, Les Toop
British Journal of General Practice 2021; 71 (708): e538-e546. DOI: 10.3399/BJGP.2020.0797
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Keywords

  • analgesia
  • general practice
  • knee osteoarthritis
  • randomised controlled trial

More in this TOC Section

  • Academic performance of ethnic minority versus White doctors in the MRCGP assessment 2016-2021: cross sectional study
  • Diagnostic delays for breathlessness: a qualitative study in primary care to understand current care and inform future pathways
  • Physical activity for chronic back pain: qualitative interviews among patients and GPs
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