TIME to take antihypertensives

Michael J Kelly

doi:10.3399/bjgp23X731517

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I too was interested in the extraordinary outcome of this single-centre trial,¹^,² and it has unquestionably influenced my practice since its publication. Thankfully, and ethics notwithstanding, this same question HAS been studied again in a UK population.²

For better or worse this large trial did not support the outcomes of the earlier study, so it is best to advise patients to take their tablets at a time most convenient for them.

REFERENCES

1.↵
1. Bal G,
2. Kim CS
(2022) Should we be advising patients to take their antihypertensives at night? [Letter]. Br J Gen Pract, DOI: https://doi.org/10.3399/bjgp22X718061.
2.↵
1. Hermida RC,
2. Crespo JJ,
3. Domínguez-Sardiña M,
4. et al.
(2020) Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial. Eur Heart J 41, 48, 4565–4576.
OpenUrl PubMed
3.
1. Mackenzie IS,
2. Rogers A,
3. Poulter NR,
4. et al.
(2022) Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial. Lancet 400, 10361, 1417–1425, doi:10.1016/S0140-6736(22)01786-X.
OpenUrl CrossRef