Nitrofurantoin is the first-choice antibiotic for treatment of uncomplicated urinary tract infections (UTIs) in males in the Dutch primary care UTI guideline. Nonetheless, the risk of nitrofurantoin failure in this condition is largely unknown. This study reports the failure fractions of nitrofurantoin compared with other commonly prescribed antibiotic treatments for uncomplicated UTIs in males. Antibiotic failure occurred in 25% of nitrofurantoin-treated episodes, increasing with age; the figures were 10% for ciprofloxacin, 20% for amoxicillin/clavulanic acid, and 14% for trimethoprim/sulfamethoxazole, not increasing with age. These results will help to inform treatment decisions regarding uncomplicated UTI in males. |