Adherence to 5-aminosalicylic acid maintenance treatment in young people with ulcerative colitis: a retrospective cohort study in primary care

Nishani Jayasooriya; Richard C Pollok; Jonathan Blackwell; Alex Bottle; Irene Petersen; Hanna Creese; Sonia Saxena

doi:10.3399/BJGP.2023.0006

Abstract

Background Maintenance treatment with 5-aminosalicylic acid (5-ASA) is recommended in ulcerative colitis (UC), but accurate estimates of discontinuation and adherence in adolescents transitioning to young adulthood are lacking.

Aim To determine rates and risk factors for discontinuation and adherence to oral 5-ASA in adolescents and young adults 1 year following diagnosis of UC.

Design and setting Observational cohort study using the UK Clinical Practice Research Datalink among adolescents and young adults (aged 10–24 years) diagnosed with UC between 1 January 1998 and 1 May 2016.

Method Time to oral 5-ASA discontinuation (days) and adherence rates (proportion of days covered) were calculated during the first year of treatment using Kaplan–Meier survival analysis. Cox regression models were built to estimate the impact of sociodemographic and health-related risk factors.

Results Among 607 adolescents and young adults starting oral 5-ASA maintenance treatment, one-quarter (n = 152) discontinued within 1 month and two- thirds (n = 419) within 1 year. Discontinuation was higher among those aged 18–24 years (74%) than younger age groups (61% and 56% in those aged 10–14 and 15–17 years, respectively). Adherence was lower among young adults than adolescents (69% in those aged 18–24 years versus 80% in those aged 10–14 years). Residents in deprived versus affluent postcodes were more likely to discontinue treatment (adjusted hazard ratio [aHR] 1.46, 95% confidence interval [CI] = 1.10 to 1.92). Early corticosteroid use for an acute flare lowered the likelihood of oral 5-ASA discontinuation (aHR 0.68, 95% CI = 0.51 to 0.90).

Conclusion The first year of starting long-term therapies in adolescents and young adults diagnosed with UC is a critical window for active follow-up of maintenance treatment, particularly in those aged 18–24 years and those living in deprived postcodes.

INTRODUCTION

The lifelong condition ulcerative colitis (UC) requires maintenance treatment in primary care; however, compliance can often be suboptimal in younger populations than in adults.¹ Long-term 5-aminosalicylic acid (5-ASA) is the first-line treatment for maintaining disease remission in UC.²^,³

Globally, the incidence of UC is rising fastest in younger populations.⁴ Up to 30% of individuals with UC are diagnosed in childhood and young adulthood, and are more likely to have a severe disease course and years lived in disability relative to those diagnosed later in life.⁴ Therefore, disease control and maintaining remission is paramount for those diagnosed in early life. Despite this, estimates suggest medication adherence rates in young people are lower than adults with inflammatory bowel disease (IBD).⁵^,⁶

International guidelines recommend 5-ASA treatment should start promptly after diagnosis and continue long term to maintain remission.²^,³ Stopping 5-ASA maintenance treatment increases the risk of early disease relapse, flare frequency, and impaired quality of life.⁷ Studies also report long-term 5-ASA treatment may reduce the risk of colorectal cancer in individuals with UC.⁸ However, some patients will need escalated immunosuppressive medications. For this group, the benefits of concurrent 5-ASA treatment to maintain remission is less clear cut.⁷

Poor medication adherence also places a significant cost burden on society and healthcare services.⁹ In the UK, disease relapse has been shown to be associated with a 20-fold increase in costs for those who required admission to hospital when compared with a two-to-threefold increase for those who did not.¹⁰ Hence, medication adherence improves health outcomes and reduces resource use in health systems.

Being diagnosed with a lifelong condition such as UC can be challenging for adolescents, who are undergoing physiological, psychological, and social transitions to adulthood.¹¹ It is important that young people learn to self-care in the early stages of long-term conditions. However, adolescents and young adults diagnosed with IBD have rated their knowledge about continuous medication as suboptimal.¹² Adolescents and young adults diagnosed with IBD perceive adhering to daily medication as a burden,¹³ with previous studies reporting a wide variation of 2%–93% and lower adherence rates compared with adults.¹^,¹⁴^–¹⁶ However, previous cross- sectional surveys, most commonly used to measure oral 5-ASA treatment adherence among adolescents, are subject to recall bias and may overestimate adherence.¹ Far less is known about the extent and timing of discontinuation.

Adolescents and young adults diagnosed with ulcerative colitis (UC) are recommended long- term maintenance treatment for disease control, but adherence rates in primary care are unknown. This observational cohort study using real-world data from primary care found one-quarter of newly diagnosed adolescents and young adults, aged 10–24 years, discontinued oral 5-aminosalicylic acid (5-ASA) maintenance treatment within 1 month of starting and two-thirds within 1 year. Young adults aged 18–24 years and those living in a deprived area were most likely to discontinue and have poor adherence to treatment. Having an acute flare-up of UC was linked to better adherence to oral 5-ASA maintenance treatment. The first year of starting lifelong therapies among individuals diagnosed with UC is a critical window to improve adherence for adolescents transitioning to young adulthood and those from deprived postcodes.

How this fits in

Qualitative studies of adolescents’ health literacy and decision making, such as adherence to medication, is influenced by social and structural determinants including health perception, health behaviours, and access to health services.¹⁷^,¹⁸ However, this is not well described in young people with chronic conditions such as UC.

A population-based study was therefore designed using prospectively collected prescribing data to determine discontinuation and adherence to oral 5-ASA maintenance in the first year of treatment among adolescents and young adults aged 10–24 years diagnosed with UC. The secondary aim was to identify risk and protective factors associated with oral 5-ASA discontinuation and adherence.

METHOD

The present study has been conducted as per recommendations provided by Strengthening the Reporting of Observational Studies in Epidemiology guidelines.¹⁹

Data source

The Clinical Practice Research Datalink (CPRD) is one of the largest validated primary care research databases in the world.²⁰ It contains the longitudinal, patient- level, anonymised electronic health records of 18 million patients from >700 general practices and is representative of the UK population.²⁰ Primary care physicians use Read codes and prodcodes to record diagnoses and prescriptions, respectively. The database’s coding system has been validated for use in IBD and the reporting of medication adherence.²¹^,²² English practice records are linked to the national hospital administrative database Hospital Episodes Statistics.

Case definition and cohort construction

The study population included individuals diagnosed with UC who started oral 5-ASA maintenance treatment aged between 10 and 24 years within 6 months of their recorded UC diagnosis date. ‘Incident cases’ with a first-ever diagnosis code for UC at least 1 year after registering with an ‘up- to- standard’ practice between 1 January 1998 and 1 May 2016 were included, in accordance with previously validated and published methods.²¹ Patients were excluded if they had codes for both UC and Crohn’s disease, or indeterminate codes (for example, ‘non- specific colitis’ and ‘colitis NOS’). Patients who had a comorbid condition that might require regular or prolonged corticosteroid use, for example, chronic asthma, polymyalgia rheumatica, and organ transplants, were also excluded to avoid potential confounding, as steroid exposure in this group is not solely for IBD.²³^,²⁴

Individuals were followed up from the oral 5-ASA start date for 1 year or until de-registration from their practice or death, whichever came first. Individuals whose coded diagnosis could not be determined and those who may have had oral 5-ASA treatment discontinued as a consequence of treatment escalation to immunomodulator therapy or if they had a colectomy during the study follow-up period were excluded. In addition, those with insufficient follow-up to identify whether they discontinued treatment during the first year (<90 days after the first break in treatment) were also excluded.⁷

Outcomes

The primary outcome measure was time to oral 5-ASA discontinuation in the first year of maintenance treatment. Oral 5-ASA use was considered as continuous if prescriptions were within 90 days of each other. This cut-off was chosen as 75% of individuals were found to receive prescriptions every 2 months. This window allowed those who continue treatment but collect prescriptions late or use existing supplies to be included.

The secondary outcome was adherence to oral 5-ASA maintenance treatment, defined as the proportion of days covered (PDC) with oral 5-ASA medication. The PDC, a validated objective measure of medication adherence, was calculated by dividing the total number of days covered from prescribed oral 5-ASA by the duration of follow-up in the first year of treatment (days). The PDC was capped at 100% to ensure measurement of adherence was not overestimated.²⁵

Predictors of oral 5-ASA discontinuation and adherence

Potential predictors of oral 5-ASA discontinuation and adherence were identified from the biomedical literature and in consultation with a panel comprising specialist gastroenterologists, GPs, and researchers (the POP-IBD group).²⁶^,²⁷

Sociodemographic predictors were:

sex;
age group when oral 5-ASA maintenance treatment started (10–14, 15–17, and 18–24 years); and
Index of Multiple Deprivation (IMD) decile, which is a postcode-based measure of socioeconomic deprivation from 1 (least deprived) to 5 (most deprived).²⁶

Health-related predictors included:

having a psychiatric comorbidity, defined as any record of depression, anxiety, or antidepressant use during the study period; or
poor health because of an acute flare of UC, defined as oral corticosteroid use within 3 months of UC diagnosis.

A proxy predictor of risky health behaviours was defined using proxy smoking status, defined as ‘smokers’, ‘ex-smokers’, or ‘non-smokers’ based on the most recent code for smoking status at UC diagnosis. Those with missing data on smoking have been shown to be either ‘never-smokers’ or ‘non-recent smokers’, and were therefore classed as ‘non- smokers’.²⁸

Finally, the impact of era during which oral 5-ASA maintenance therapy was started was examined to account for secular changes in 5-ASA use over the study period (era 1: 1998–2002; era 2: 2003–2007; era 3: 2008–2012; and era 4: 2013–2016).

Data analysis

Kaplan–Meier analysis was used to estimate time from the start of oral 5-ASA maintenance treatment to discontinuation. The PDC was calculated for each individual as a percentage of the first year covered with oral 5-ASA maintenance treatment.

In each model, where a potential predictor of oral 5-ASA discontinuation and adherence was examined, the probable blocks of mediators were determined and potential confounders adjusted for. Cox regression analysis was used to determine hazard ratios (HRs) for the risk of oral 5-ASA discontinuation in the year after starting maintenance treatment. Cox regression analysis was used so it was possible to account for the time each individual was at risk of oral 5-ASA discontinuation. Simple and multiple linear regression analysis was used to determine predictors associated with adherence to oral 5-ASA in the first year of maintenance treatment.

All analyses were performed using Stata (version 17) software.

RESULTS

A total of 607 adolescents and young adults were identified with an incident diagnosis of UC who started oral 5-ASA maintenance treatment, excluding 48 individuals who required treatment escalation in the first year of starting oral 5-ASA and 109 ineligible individuals because of insufficient follow-up (Figure 1). Baseline characteristics of the study population can be found in Table 1.

Figure 1.

Cohort construction.

5-ASA = 5-aminosalicylic acid. CPRD = Clinical Practice Research Datalink. UC = ulcerative colitis.

View this table:

Table 1.

Baseline characteristics of study population

Overall, 69% (n = 419) of individuals discontinued oral 5-ASA maintenance treatment within 1 year of starting (Figure 2a). One-quarter (n = 152) of the cohort discontinued treatment by day 34. The median time to discontinuation was 162 days (data not shown). Among individuals who discontinued oral 5-ASA, 90% (n = 379/420) had no subsequent prescription in the first year of treatment.

Figure 2.

Kaplan–Meier curve demonstrating probability of oral 5-ASA discontinuation in the first year of treatment for a) all adolescents and young adults, and b) by age at oral 5-ASA initiation. 5-ASA = 5-aminosalicylic acid.

Discontinuation rates at 1 year were lowest in younger adolescents (56% in those aged 15–17 years and 61% in those aged 10–14 years) and highest among young adults aged 18–24 years (74%) (Figure 2b). Among young adults aged 18–24 years, 28% discontinued oral 5-ASA maintenance treatment after a single prescription, compared with 19% and 15% of adolescents starting treatment at 10–14 and 15–17 years, respectively (data not shown).

Mean adherence for the study population in the first year of oral 5-ASA maintenance treatment was 72% (95% confidence interval [CI] = 70 to 75), equivalent to just under 9 months’ duration in the first 12 months of treatment. Adherence fell with older age at oral 5-ASA initiation. This was 80% (95% CI = 74 to 86) among adolescents aged 10–14 years, 78% (95% CI = 72 to 84) among adolescents aged 15–17 years, and 69% (95% CI = 66 to 72) among young adults aged 18–24 years (data not shown).

Risk and protective factors for oral 5-ASA discontinuation and adherence

Young adults aged 18–24 years starting oral 5-ASA were more likely to discontinue maintenance treatment in the first 12 months compared with adolescents aged 10–14 years (adjusted hazard ratio [aHR] 1.43, 95% CI =1.04 to 1.97). Individuals living in deprived versus affluent postcodes were more likely to discontinue oral 5-ASA maintenance treatment (aHR 1.46, 95% CI = 1.10 to 1.92). Individuals who experienced a UC flare requiring early oral corticosteroids were less likely to discontinue oral 5-ASA maintenance treatment compared with individuals who did not require corticosteroids (aHR 0.68, 95% CI = 0.51 to 0.90; Table 2).

View this table:

Table 2.

Predictors of oral 5-ASA treatment discontinuation^a

Predictors of lower adherence included starting treatment during young adulthood (aged 18–24 years) and living in poorer postcodes. Individuals who had an acute flare and required early corticosteroid use had higher adherence to oral 5-ASA maintenance treatment (Table 3).

View this table:

Table 3.

Predictors of adherence to oral 5-ASA treatment^a

Psychiatric comorbidity of depression, anxiety, or antidepressant use was not associated with discontinuation or adherence to oral 5-ASA maintenance treatment (Tables 2 and 3).

DISCUSSION

Summary

One-quarter of adolescents and young adults newly diagnosed with UC discontinued oral 5-ASA maintenance treatment within 1 month and two- thirds within 1 year. Of those who discontinued, 90% had no subsequent oral 5-ASA prescription in the first year of treatment. Adolescents and young adults adhered to oral 5-ASA maintenance treatment for an average of 9 months in the first year of starting.

Young adults aged 18–24 years and those living in deprived postcode areas were 43% and 46% more likely to discontinue oral 5-ASA maintenance treatment, respectively. By contrast, those with an acute flare who required corticosteroids during the early stages of diagnosis were more likely to continue and adhere to oral 5-ASA maintenance in the first year of treatment.

Strengths and limitations

This is the first population-based study, to the authors’ knowledge, to objectively examine discontinuation and adherence of oral 5-ASA maintenance treatment among adolescents, including the transition period into early adulthood. Real-world data were used, drawn from a large nationally representative validated primary care database that captures a high level of community prescribing. CPRD data are collected at the time of consultation or prescription and are therefore independent of referral centre, recall, or participant selection bias.

Important limitations in the current study are an assumption that repeat prescriptions issued in primary care were indicative of adherence. Hence, discontinuation rates may be higher and adherence lower than reported in this study. In the UK, hospital outpatient prescribing is highly regulated and primary care physicians are responsible for prescribing for patients with chronic conditions in the community. However, it was not possible to capture a small minority of short-term prescriptions given in hospital at discharge after admission, in the private sector, or obtained overseas.

Comparison with existing literature

To the authors’ knowledge, the current study is among the largest population- based cohort studies of incident cases of adolescents and young adults diagnosed with UC. Previous studies of oral 5-ASA adherence among adolescents have reported lower objective adherence rates of 52%–71%.¹⁴^,²⁹ These studies have focused on populations drawn from single centres or have been about individuals aged <18 years, and do not capture this transition period to young adulthood.¹^,¹⁴

In the current study, strict inclusion criteria were applied for the cohort construction to ensure robust case ascertainment. The sample size of 607 new cases is consistent with the incidence of UC of approximately 10–20 patients per 100 000 per year reported elsewhere.³⁰

The current finding that approximately one-quarter of patients discontinue oral 5-ASA maintenance treatment after 1 month is consistent with discontinuation rates in adults with IBD.³¹ This study’s objective estimate of 72% oral 5-ASA adherence among adolescents and young adults is much lower than self-reported estimates of 93%–96% from previous studies that are subject to recall bias.³²^,³³ Using electronic records for measuring discontinuation and adherence overcomes reporting bias seen in previous studies because patients and families are not aware they are being evaluated.¹

The relapsing and remitting course of UC may influence the perceived importance of maintenance treatment. The estimated mean time to control symptoms with 5-ASA in UC is reported to be 4 weeks.³⁴ It may be that, once symptoms resolve, the motivation to persist with treatment falters. Some individuals may not perceive themselves to be at risk of long-term consequences of the illness, an important motivator to continue treatment. Conversely, those who experience disease flares may find it easier to accept the need for maintenance treatment. This may explain this study’s findings that the risk of oral 5-ASA treatment discontinuation was lower and adherence higher among those who had a flare treated with corticosteroids during the early stages of disease.

The findings from the current research of higher risk of treatment discontinuation and poor adherence during the transition from adolescence to adulthood may be explained by the loss of support from caregivers who encourage adherence in adolescents and provide financial and practical support.³⁵ Previous literature is conflicting about the impact of poor mental health on medication adherence.³²^,³⁶^,³⁷ In the current study it was not found that adolescents and young adults with depression, anxiety, or antidepressant use had poor adherence or discontinued oral 5-ASA maintenance treatment. It is possible that the association between poor mental health was underestimated, as depression and anxiety may not be detected or coded for in primary care, and low medication adherence is associated with concurrent psychiatric comorbidity.³⁷

Implications for research and practice

The current findings may mean that adolescents and young adults diagnosed with UC are at a high risk of early relapse. Non-adherence to 5-ASA (PDC <80%) is associated with a five-fold risk of disease relapse compared with those whose adherence is over 80%.³⁸ The current study found a mean adherence rate of 72% among adolescents and young adults in their first year of oral 5-ASA maintenance treatment. If clinicians are unaware of suboptimal adherence to first-line medication they may incorrectly assume therapy has failed, which may lead to unnecessary escalation in treatment and avoidable steroid use that remains high in UC.³⁹ The methods used in the current study have application for future studies and clinical audits to assess adherence to long-term medication using electronic records. Future longitudinal studies using linked data on prescribed treatments in primary care and hospital settings are needed to identify the impact of poor adherence and discontinuation on clinical outcomes of UC.

Clear communication about the importance of regular maintenance for adolescents and young adults should be coupled with an action plan for managing their chronic condition. For example, it is a common misconception that treatment should be discontinued when symptoms resolve in other inflammatory conditions such as asthma. Structured transition programmes from paediatric to adult health care can empower adolescents by providing them with the knowledge and skills to manage their own disease.⁴⁰^,⁴¹ Although developing patient autonomy for managing their condition is a prerequisite for good adherence, the current study supports findings of a recent patient survey and self- assessment of 134 IBD services in the UK that found two-thirds of services scored below standard on their transition care pathways.⁴²

A survey of GPs in the 2017 Royal College of General Practitioners IBD ‘Spotlight’ project reported 50% lacked confidence in managing IBD.⁴³ Prescribing physicians are often under pressure to reduce health system costs by issuing shorter prescriptions or deprescribing long-term medications. However, it has been argued that this may have adverse long-term health and economic consequences for patients with chronic conditions.⁴³ Based on the findings in the current study, the authors recommend better integration to agree roles and responsibilities between primary and secondary care as this could improve adherence during the early stages of starting treatment.

This study highlights the need to address socioeconomic disparities that could be driving oral 5-ASA discontinuation and low adherence among adolescents and young adults who may struggle with meeting the costs of long-term prescriptions.⁴⁴ In the US, an increase in each dollar of medication co-payment decreases medication adherence rates by 0.4%.⁴⁴ Even in the UK, where 98% of patients have access to universal healthcare coverage, one-third of individuals with IBD paying prescription charges do not pick up a prescription because of cost, and 15% take medicines less frequently than required to reduce costs.⁴⁵

In conclusion, adolescents and young adults diagnosed with UC starting oral 5-ASA maintenance treatment are at risk of discontinuation and poor adherence, a majority of whom discontinue early in the first year of treatment. These findings illustrate the importance of clinicians ensuring careful follow-up within the first year when prescribing lifelong therapies for adolescents and young adults who are diagnosed with UC, particularly adolescents transitioning to young adulthood and those living in deprived areas.

Notes

Funding

Jonathan Blackwell was funded by a Crohn’s & Colitis UK grant (grant number: SP2018/3). Sonia Saxena is funded by the National Institute for Health and Care Research (NIHR) Senior Investigator Award, NIHR School for Public Health Research (SPHR) (grant number: NIHR 204000), NIHR Northwest London Applied Research Collaboration, and Imperial NIHR Biomedical Research Centre. The NIHR SPHR is a partnership between the Universities of Bristol, Cambridge, and Sheffield; Imperial; University College London; the London School of Hygiene and Tropical Medicine; LiLaC — a collaboration between the Universities of Liverpool and Lancaster; and Fuse — the Centre for Translational Research in Public Health, a collaboration between Newcastle, Durham, Northumbria, Sunderland, and Teesside Universities. Alex Bottle’s Unit at Imperial College London is affiliated with the NIHR Imperial Patient Safety Translational Research Centre. The NIHR Imperial Patient Safety Translational Centre is a partnership between the Imperial College Healthcare NHS Trust and Imperial College London. Alex Bottle’s Unit at Imperial College London is also grateful for support from the NIHR Biomedical Research Centre funding scheme. The views expressed in this publication are those of the authors and not necessarily those of Crohn’s & Colitis UK, the NHS, the NIHR, or the Department of Health and Social Care.

Ethical approval

Ethical approval was received from the Independent Scientific Advisory Committee (protocol number: 15_018R).

Data

Data may be obtained from the Clinical Practice Research Datalink and are not publicly available.

Provenance

Freely submitted; externally peer reviewed.

Competing interests

The authors have declared no competing interests.

Contributors

The POP-IBD study group is a collaboration between St George’s, University of London, Imperial College London, University College London, and King’s College London, conducting population-based studies in the field of inflammatory bowel disease.

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Received January 3, 2023.
Revision requested March 23, 2023.
Accepted May 16, 2023.

http://creativecommons.org/licenses/by/4.0/

This article is Open Access: CC BY 4.0 licence (http://creativecommons.org/licences/by/4.0/).

REFERENCES

1.↵
1. Spekhorst LM,
2. Hummel TZ,
3. Benning MA,
4. et al.
(2016) Adherence to oral maintenance treatment in adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 62, 2, 264–270.
OpenUrl
2.↵
1. Raine T,
2. Bonovas S,
3. Burisch J,
4. et al.
(2022) ECCO guidelines on therapeutics in ulcerative colitis: medical treatment. J Crohns Colitis 16, 1, 2–17.
OpenUrl PubMed
3.↵
1. Turner D,
2. Ruemmele FM,
3. Orlanski-Meyer E,
4. et al.
(2018) Management of paediatric ulcerative colitis, part 1: ambulatory care — an evidence-based Guideline from European Crohn’s and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 67, 2, 257–291.
OpenUrl PubMed
4.↵
1. Alatab S,
2. Sepanlou SG,
3. Ikuta K,
4. et al.
(2020) The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol 5, 1, 17–30.
OpenUrl
5.↵
1. Goodhand JR,
2. Kamperidis N,
3. Sirwan B,
4. et al.
(2013) Factors associated with thiopurine non-adherence in patients with inflammatory bowel disease. Aliment Pharmacol Ther 38, 9, 1097–1108.
OpenUrl PubMed
6.↵
1. Tae CH,
2. Jung SA,
3. Moon HS,
4. et al.
(2016) Importance of patients’ knowledge of their prescribed medication in improving treatment adherence in inflammatory bowel disease. J Clin Gastroenterol 50, 2, 157–162.
OpenUrl
7.↵
1. Chapman TP,
2. Frias Gomes C,
3. Louis E,
4. et al.
(2020) Review article: withdrawal of 5-aminosalicylates in inflammatory bowel disease. Aliment Pharmacol Ther 52, 1, 73–84.
OpenUrl
8.↵
1. Qiu X,
2. Ma J,
3. Wang K,
4. Zhang H
(2017) Chemopreventive effects of 5-aminosalicylic acid on inflammatory bowel disease-associated colorectal cancer and dysplasia: a systematic review with meta-analysis. Oncotarget 8, 1, 1031–1045.
OpenUrl CrossRef
9.↵
1. Kane SV
(2006) Systematic review: adherence issues in the treatment of ulcerative colitis. Aliment Pharmacol Ther 23, 5, 577–585.
OpenUrl CrossRef PubMed
10.↵
1. Bassi A,
2. Dodd S,
3. Williamson P,
4. Bodger K
(2004) Cost of illness of inflammatory bowel disease in the UK: a single centre retrospective study. Gut 53, 10, 1471–1478.
OpenUrl Abstract/FREE Full Text
11.↵
1. Santos T,
2. de Matos MG,
3. Marques A,
4. et al.
(2016) Adolescent’s subjective perceptions of chronic disease and related psychosocial factors: highlights from an outpatient context study. BMC Pediatr 16, 1, 211.
OpenUrl
12.↵
1. Gumidyala AP,
2. Plevinsky JM,
3. Poulopoulos N,
4. et al.
(2017) What teens do not know can hurt them: an assessment of disease knowledge in adolescents and young adults with IBD. Inflamm Bowel Dis 23, 1, 89–96.
OpenUrl
13.↵
1. Loonen HJ,
2. Derkx BHHF,
3. Griffiths AM
(2002) Pediatricians overestimate importance of physical symptoms upon children’s health concerns. Med Care 40, 10, 996–1001.
OpenUrl CrossRef PubMed
14.↵
1. LeLeiko NS,
2. Lobato D,
3. Hagin S,
4. et al.
(2013) Rates and predictors of oral medication adherence in pediatric patients with IBD. Inflamm Bowel Dis 19, 4, 832–916.
OpenUrl CrossRef PubMed
15.
1. Hanghøj S,
2. Boisen KA
(2014) Self-reported barriers to medication adherence among chronically ill adolescents: a systematic review. J Adolesc Health 54, 2, 121–138.
OpenUrl CrossRef PubMed
16.↵
1. Kamperidis N,
2. Goodhand JR,
3. Chowdhury FA,
4. et al.
(2012) Factors associated with nonadherence to thiopurines in adolescent and adult patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 54, 5, 685–689.
OpenUrl PubMed
17.↵
1. Fleary SA,
2. Joseph P
(2020) Adolescents’ health literacy and decision-making: a qualitative study. Am J Health Behav 44, 4, 392–408.
OpenUrl
18.↵
1. Sørensen K,
2. Van den Broucke S,
3. Fullam J,
4. et al.
(2012) Health literacy and public health: a systematic review and integration of definitions and models. BMC Public Health 12, 80.
OpenUrl CrossRef PubMed
19.↵
1. Elm E von,
2. Altman DG,
3. Egger M,
4. et al.
(2007) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370, 9596, 1453–1457.
OpenUrl CrossRef PubMed
20.↵
1. Herrett E,
2. Gallagher AM,
3. Bhaskaran K,
4. et al.
(2015) Data Resource Profile: Clinical Practice Research Datalink (CPRD). Int J Epidemiol 44, 3, 827–836.
OpenUrl CrossRef PubMed
21.↵
1. Lewis JD,
2. Brensinger C,
3. Bilker WB,
4. Strom BL
(2002) Validity and completeness of the General Practice Research Database for studies of inflammatory bowel disease. Pharmacoepidemiol Drug Saf 11, 3, 211–218.
OpenUrl CrossRef PubMed
22.↵
1. Gordon J,
2. McEwan P,
3. Idris I,
4. et al.
(2018) Treatment choice, medication adherence and glycemic efficacy in people with type 2 diabetes: a UK clinical practice database study. BMJ Open Diabetes Res Care 6, 1, e000512.
OpenUrl Abstract/FREE Full Text
23.↵
1. Blackwell J,
2. Saxena S,
3. Jayasooriya N,
4. et al.
(2020) Prevalence and duration of gastrointestinal symptoms before diagnosis of inflammatory bowel disease and predictors of timely specialist review: a population-based study. J Crohns Colitis doi:10.1093/ecco-jcc/jjaa146.
OpenUrl CrossRef
24.↵
1. Blackwell J,
2. Saxena S,
3. Petersen I,
4. et al.
(2021) Depression in individuals who subsequently develop inflammatory bowel disease: a population-based nested case–control study. Gut 70, 9, 1642–1648.
OpenUrl Abstract/FREE Full Text
25.↵
1. US Centers for Medicare & Medicaid Services
(2023) Part C and D performance data (US Centers for Medicare & Medicaid Services, Baltimore, MD).
26.↵
1. Wadhwani SI,
2. Bucuvalas JC,
3. Brokamp C,
4. et al.
(2020) Association between neighborhood-level socioeconomic deprivation and the medication level variability index for children following liver transplantation. Transplantation 104, 11, 2346–2353.
OpenUrl
27.↵
1. Aggarwal B,
2. Mosca L
(2010) Lifestyle and psychosocial risk factors predict non-adherence to medication. Ann Behav Med 40, 2, 228–233.
OpenUrl CrossRef PubMed
28.↵
(2023) Joint Strategic Needs Assessment Blackpool. Tobacco use in children and young people (Blackpool Council, Blackpool).
29.↵
1. Hommel KA,
2. Davis CM,
3. Baldassano RN
(2008) Medication adherence and quality of life in pediatric inflammatory bowel disease. J Pediatr Psychol 33, 8, 867–874.
OpenUrl CrossRef PubMed
30.↵
1. Pasvol TJ,
2. Horsfall L,
3. Bloom S,
4. et al.
(2020) Incidence and prevalence of inflammatory bowel disease in UK primary care: a population-based cohort study. BMJ Open 10, 7, e036584.
OpenUrl Abstract/FREE Full Text
31.↵
1. Yen L,
2. Wu J,
3. Hodgkins PL,
4. et al.
(2012) Medication use patterns and predictors of non-persistence and nonadherence with oral 5-aminosalicylic acid therapy in patients with ulcerative colitis. J Manag Care Pharm 18, 9, 701–712.
OpenUrl PubMed
32.↵
1. Hommel KA,
2. Hente EA,
3. Odell S,
4. et al.
(2012) Evaluation of a group-based behavioral intervention to promote adherence in adolescents with inflammatory bowel disease. Eur J Gastroenterol Hepatol 24, 1, 64–69.
OpenUrl CrossRef PubMed
33.↵
1. Hommel KA,
2. Denson LA,
3. Baldassano RN
(2011) Oral medication adherence and disease severity in pediatric inflammatory bowel disease. Eur J Gastroenterol Hepatol 23, 3, 250–254.
OpenUrl CrossRef PubMed
34.↵
1. Turner D,
2. Ricciuto A,
3. Lewis A,
4. et al.
(2021) STRIDE-II: an update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD. Gastroenterology 160, 5, 1570–1583.
OpenUrl CrossRef PubMed
35.↵
1. Berglund E,
2. Lytsy P,
3. Westerling R
(2019) Living environment, social support, and informal caregiving are associated with healthcare seeking behaviour and adherence to medication treatment: a cross-sectional population study. Health Soc Care Community 27, 5, 1260–1270.
OpenUrl
36.↵
1. Selinger CP,
2. Eaden J,
3. Jones DB,
4. et al.
(2013) Modifiable factors associated with nonadherence to maintenance medication for inflammatory bowel disease. Inflamm Bowel Dis 19, 10, 2199–2206.
OpenUrl CrossRef PubMed
37.↵
1. Gray WN,
2. Denson LA,
3. Baldassano RN,
4. Hommel KA
(2012) Treatment adherence in adolescents with inflammatory bowel disease: the collective impact of barriers to adherence and anxiety/depressive symptoms. J Pediatr Psychol 37, 3, 282–291.
OpenUrl CrossRef PubMed
38.↵
1. Kane S,
2. Huo D,
3. Aikens J,
4. Hanauer S
(2003) Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis. Am J Med 114, 1, 39–43.
OpenUrl CrossRef PubMed
39.↵
1. Selinger CP,
2. Parkes GC,
3. Bassi A,
4. et al.
(2019) Assessment of steroid use as a key performance indicator in inflammatory bowel disease — analysis of data from 2385 UK patients. Aliment Pharmacol Ther 50, 9, 1009–1018.
OpenUrl PubMed
40.↵
1. Cole R,
2. Ashok D,
3. Razack A,
4. et al.
(2015) Evaluation of outcomes in adolescent inflammatory bowel disease patients following transfer from pediatric to adult health care services: case for transition. J Adolesc Health 57, 2, 212–217.
OpenUrl PubMed
41.↵
1. Brooks AJ,
2. Smith PJ,
3. Cohen R,
4. et al.
(2017) UK guideline on transition of adolescent and young persons with chronic digestive diseases from paediatric to adult care. Gut 66, 6, 988–1000.
OpenUrl Abstract/FREE Full Text
42.↵
1. Hawthorne AB,
2. Glatter J,
3. Blackwell J,
4. et al.
(2022) Inflammatory bowel disease patient-reported quality assessment should drive service improvement: a national survey of UK IBD units and patients. Aliment Pharmacol Ther 56, 4, 625–645.
OpenUrl
43.↵
1. Crohn’s & Colitis UK
(2019) RCGP IBD Spotlight Report to enter its third year. https://crohnsandcolitis.org.uk/our-work/healthcare-professionals/the-healthcare-professional-blog/the-healthcare-professional-blog/rcgp-ibd-spotlight-report-to-enter-its-third-year (accessed 15 Aug 2023).
44.↵
1. Matsui D
(2013) Medication adherence issues in patients: focus on cost. Clinical Audit 5, 33–42.
OpenUrl
45.↵
1. Hex N,
2. Mahon J,
3. Webb A
(2018) Economic evaluation of the benefits of extending free prescriptions to people with long-term conditions, https://www.prescriptionchargescoalition.org.uk/uploads/1/2/7/5/12754304/economic_evaluation_report.pdf (accessed 15 Aug 2023).

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[1] 1.↵
Spekhorst LM,
Hummel TZ,
Benning MA,
et al.
(2016) Adherence to oral maintenance treatment in adolescents with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 62, 2, 264–270.
OpenUrl

[2] Spekhorst LM,

[3] Hummel TZ,

[4] Benning MA,

[5] et al.

[6] 2.↵
Raine T,
Bonovas S,
Burisch J,
et al.
(2022) ECCO guidelines on therapeutics in ulcerative colitis: medical treatment. J Crohns Colitis 16, 1, 2–17.
OpenUrl PubMed

[7] Raine T,

[8] Bonovas S,

[9] Burisch J,

[10] et al.

[11] 3.↵
Turner D,
Ruemmele FM,
Orlanski-Meyer E,
et al.
(2018) Management of paediatric ulcerative colitis, part 1: ambulatory care — an evidence-based Guideline from European Crohn’s and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 67, 2, 257–291.
OpenUrl PubMed

[12] Turner D,

[13] Ruemmele FM,

[14] Orlanski-Meyer E,

[15] et al.

[16] 4.↵
Alatab S,
Sepanlou SG,
Ikuta K,
et al.
(2020) The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol 5, 1, 17–30.
OpenUrl

[17] Alatab S,

[18] Sepanlou SG,

[19] Ikuta K,

[20] et al.

[21] 5.↵
Goodhand JR,
Kamperidis N,
Sirwan B,
et al.
(2013) Factors associated with thiopurine non-adherence in patients with inflammatory bowel disease. Aliment Pharmacol Ther 38, 9, 1097–1108.
OpenUrl PubMed

[22] Goodhand JR,

[23] Kamperidis N,

[24] Sirwan B,

[25] et al.

[26] 6.↵
Tae CH,
Jung SA,
Moon HS,
et al.
(2016) Importance of patients’ knowledge of their prescribed medication in improving treatment adherence in inflammatory bowel disease. J Clin Gastroenterol 50, 2, 157–162.
OpenUrl

[27] Tae CH,

[28] Jung SA,

[29] Moon HS,

[30] et al.

[31] 7.↵
Chapman TP,
Frias Gomes C,
Louis E,
et al.
(2020) Review article: withdrawal of 5-aminosalicylates in inflammatory bowel disease. Aliment Pharmacol Ther 52, 1, 73–84.
OpenUrl

[32] Chapman TP,

[33] Frias Gomes C,

[34] Louis E,

[35] et al.

[36] 8.↵
Qiu X,
Ma J,
Wang K,
Zhang H
(2017) Chemopreventive effects of 5-aminosalicylic acid on inflammatory bowel disease-associated colorectal cancer and dysplasia: a systematic review with meta-analysis. Oncotarget 8, 1, 1031–1045.
OpenUrl CrossRef

[37] Qiu X,

[38] Ma J,

[39] Wang K,

[40] Zhang H

[41] 9.↵
Kane SV
(2006) Systematic review: adherence issues in the treatment of ulcerative colitis. Aliment Pharmacol Ther 23, 5, 577–585.
OpenUrl CrossRef PubMed

[42] Kane SV

[43] 10.↵
Bassi A,
Dodd S,
Williamson P,
Bodger K
(2004) Cost of illness of inflammatory bowel disease in the UK: a single centre retrospective study. Gut 53, 10, 1471–1478.
OpenUrl Abstract/FREE Full Text

[44] Bassi A,

[45] Dodd S,

[46] Williamson P,

[47] Bodger K

[48] 11.↵
Santos T,
de Matos MG,
Marques A,
et al.
(2016) Adolescent’s subjective perceptions of chronic disease and related psychosocial factors: highlights from an outpatient context study. BMC Pediatr 16, 1, 211.
OpenUrl

[49] Santos T,

[50] de Matos MG,

[51] Marques A,

[52] et al.

[53] 12.↵
Gumidyala AP,
Plevinsky JM,
Poulopoulos N,
et al.
(2017) What teens do not know can hurt them: an assessment of disease knowledge in adolescents and young adults with IBD. Inflamm Bowel Dis 23, 1, 89–96.
OpenUrl

[54] Gumidyala AP,

[55] Plevinsky JM,

[56] Poulopoulos N,

[57] et al.

[58] 13.↵
Loonen HJ,
Derkx BHHF,
Griffiths AM
(2002) Pediatricians overestimate importance of physical symptoms upon children’s health concerns. Med Care 40, 10, 996–1001.
OpenUrl CrossRef PubMed

[59] Loonen HJ,

[60] Derkx BHHF,

[61] Griffiths AM

[62] 14.↵
LeLeiko NS,
Lobato D,
Hagin S,
et al.
(2013) Rates and predictors of oral medication adherence in pediatric patients with IBD. Inflamm Bowel Dis 19, 4, 832–916.
OpenUrl CrossRef PubMed

[63] LeLeiko NS,

[64] Lobato D,

[65] Hagin S,

[66] et al.

[67] 15.
Hanghøj S,
Boisen KA
(2014) Self-reported barriers to medication adherence among chronically ill adolescents: a systematic review. J Adolesc Health 54, 2, 121–138.
OpenUrl CrossRef PubMed

[68] Hanghøj S,

[69] Boisen KA

[70] 16.↵
Kamperidis N,
Goodhand JR,
Chowdhury FA,
et al.
(2012) Factors associated with nonadherence to thiopurines in adolescent and adult patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 54, 5, 685–689.
OpenUrl PubMed

[71] Kamperidis N,

[72] Goodhand JR,

[73] Chowdhury FA,

[74] et al.

[75] 17.↵
Fleary SA,
Joseph P
(2020) Adolescents’ health literacy and decision-making: a qualitative study. Am J Health Behav 44, 4, 392–408.
OpenUrl

[76] Fleary SA,

[77] Joseph P

[78] 18.↵
Sørensen K,
Van den Broucke S,
Fullam J,
et al.
(2012) Health literacy and public health: a systematic review and integration of definitions and models. BMC Public Health 12, 80.
OpenUrl CrossRef PubMed

[79] Sørensen K,

[80] Van den Broucke S,

[81] Fullam J,

[82] et al.

[83] 19.↵
Elm E von,
Altman DG,
Egger M,
et al.
(2007) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet 370, 9596, 1453–1457.
OpenUrl CrossRef PubMed

[84] Elm E von,

[85] Altman DG,

[86] Egger M,

[87] et al.

[88] 20.↵
Herrett E,
Gallagher AM,
Bhaskaran K,
et al.
(2015) Data Resource Profile: Clinical Practice Research Datalink (CPRD). Int J Epidemiol 44, 3, 827–836.
OpenUrl CrossRef PubMed

[89] Herrett E,

[90] Gallagher AM,

[91] Bhaskaran K,

[92] et al.

[93] 21.↵
Lewis JD,
Brensinger C,
Bilker WB,
Strom BL
(2002) Validity and completeness of the General Practice Research Database for studies of inflammatory bowel disease. Pharmacoepidemiol Drug Saf 11, 3, 211–218.
OpenUrl CrossRef PubMed

[94] Lewis JD,

[95] Brensinger C,

[96] Bilker WB,

[97] Strom BL

[98] 22.↵
Gordon J,
McEwan P,
Idris I,
et al.
(2018) Treatment choice, medication adherence and glycemic efficacy in people with type 2 diabetes: a UK clinical practice database study. BMJ Open Diabetes Res Care 6, 1, e000512.
OpenUrl Abstract/FREE Full Text

[99] Gordon J,

[100] McEwan P,

[101] Idris I,

[102] et al.

[103] 23.↵
Blackwell J,
Saxena S,
Jayasooriya N,
et al.
(2020) Prevalence and duration of gastrointestinal symptoms before diagnosis of inflammatory bowel disease and predictors of timely specialist review: a population-based study. J Crohns Colitis doi:10.1093/ecco-jcc/jjaa146.
OpenUrl CrossRef

[104] Blackwell J,

[105] Saxena S,

[106] Jayasooriya N,

[107] et al.

[108] 24.↵
Blackwell J,
Saxena S,
Petersen I,
et al.
(2021) Depression in individuals who subsequently develop inflammatory bowel disease: a population-based nested case–control study. Gut 70, 9, 1642–1648.
OpenUrl Abstract/FREE Full Text

[109] Blackwell J,

[110] Saxena S,

[111] Petersen I,

[112] et al.

[113] 25.↵
US Centers for Medicare & Medicaid Services
(2023) Part C and D performance data (US Centers for Medicare & Medicaid Services, Baltimore, MD).

[114] US Centers for Medicare & Medicaid Services

[115] 26.↵
Wadhwani SI,
Bucuvalas JC,
Brokamp C,
et al.
(2020) Association between neighborhood-level socioeconomic deprivation and the medication level variability index for children following liver transplantation. Transplantation 104, 11, 2346–2353.
OpenUrl

[116] Wadhwani SI,

[117] Bucuvalas JC,

[118] Brokamp C,

[119] et al.

[120] 27.↵
Aggarwal B,
Mosca L
(2010) Lifestyle and psychosocial risk factors predict non-adherence to medication. Ann Behav Med 40, 2, 228–233.
OpenUrl CrossRef PubMed

[121] Aggarwal B,

[122] Mosca L

[123] 28.↵
(2023) Joint Strategic Needs Assessment Blackpool. Tobacco use in children and young people (Blackpool Council, Blackpool).

[124] 29.↵
Hommel KA,
Davis CM,
Baldassano RN
(2008) Medication adherence and quality of life in pediatric inflammatory bowel disease. J Pediatr Psychol 33, 8, 867–874.
OpenUrl CrossRef PubMed

[125] Hommel KA,

[126] Davis CM,

[127] Baldassano RN

[128] 30.↵
Pasvol TJ,
Horsfall L,
Bloom S,
et al.
(2020) Incidence and prevalence of inflammatory bowel disease in UK primary care: a population-based cohort study. BMJ Open 10, 7, e036584.
OpenUrl Abstract/FREE Full Text

[129] Pasvol TJ,

[130] Horsfall L,

[131] Bloom S,

[132] et al.

[133] 31.↵
Yen L,
Wu J,
Hodgkins PL,
et al.
(2012) Medication use patterns and predictors of non-persistence and nonadherence with oral 5-aminosalicylic acid therapy in patients with ulcerative colitis. J Manag Care Pharm 18, 9, 701–712.
OpenUrl PubMed

[134] Yen L,

[135] Wu J,

[136] Hodgkins PL,

[137] et al.

[138] 32.↵
Hommel KA,
Hente EA,
Odell S,
et al.
(2012) Evaluation of a group-based behavioral intervention to promote adherence in adolescents with inflammatory bowel disease. Eur J Gastroenterol Hepatol 24, 1, 64–69.
OpenUrl CrossRef PubMed

[139] Hommel KA,

[140] Hente EA,

[141] Odell S,

[142] et al.

[143] 33.↵
Hommel KA,
Denson LA,
Baldassano RN
(2011) Oral medication adherence and disease severity in pediatric inflammatory bowel disease. Eur J Gastroenterol Hepatol 23, 3, 250–254.
OpenUrl CrossRef PubMed

[144] Hommel KA,

[145] Denson LA,

[146] Baldassano RN

[147] 34.↵
Turner D,
Ricciuto A,
Lewis A,
et al.
(2021) STRIDE-II: an update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD. Gastroenterology 160, 5, 1570–1583.
OpenUrl CrossRef PubMed

[148] Turner D,

[149] Ricciuto A,

[150] Lewis A,

[151] et al.

[152] 35.↵
Berglund E,
Lytsy P,
Westerling R
(2019) Living environment, social support, and informal caregiving are associated with healthcare seeking behaviour and adherence to medication treatment: a cross-sectional population study. Health Soc Care Community 27, 5, 1260–1270.
OpenUrl

[153] Berglund E,

[154] Lytsy P,

[155] Westerling R

[156] 36.↵
Selinger CP,
Eaden J,
Jones DB,
et al.
(2013) Modifiable factors associated with nonadherence to maintenance medication for inflammatory bowel disease. Inflamm Bowel Dis 19, 10, 2199–2206.
OpenUrl CrossRef PubMed

[157] Selinger CP,

[158] Eaden J,

[159] Jones DB,

[160] et al.

[161] 37.↵
Gray WN,
Denson LA,
Baldassano RN,
Hommel KA
(2012) Treatment adherence in adolescents with inflammatory bowel disease: the collective impact of barriers to adherence and anxiety/depressive symptoms. J Pediatr Psychol 37, 3, 282–291.
OpenUrl CrossRef PubMed

[162] Gray WN,

[163] Denson LA,

[164] Baldassano RN,

[165] Hommel KA

[166] 38.↵
Kane S,
Huo D,
Aikens J,
Hanauer S
(2003) Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis. Am J Med 114, 1, 39–43.
OpenUrl CrossRef PubMed

[167] Kane S,

[168] Huo D,

[169] Aikens J,

[170] Hanauer S

[171] 39.↵
Selinger CP,
Parkes GC,
Bassi A,
et al.
(2019) Assessment of steroid use as a key performance indicator in inflammatory bowel disease — analysis of data from 2385 UK patients. Aliment Pharmacol Ther 50, 9, 1009–1018.
OpenUrl PubMed

[172] Selinger CP,

[173] Parkes GC,

[174] Bassi A,

[175] et al.

[176] 40.↵
Cole R,
Ashok D,
Razack A,
et al.
(2015) Evaluation of outcomes in adolescent inflammatory bowel disease patients following transfer from pediatric to adult health care services: case for transition. J Adolesc Health 57, 2, 212–217.
OpenUrl PubMed

[177] Cole R,

[178] Ashok D,

[179] Razack A,

[180] et al.

[181] 41.↵
Brooks AJ,
Smith PJ,
Cohen R,
et al.
(2017) UK guideline on transition of adolescent and young persons with chronic digestive diseases from paediatric to adult care. Gut 66, 6, 988–1000.
OpenUrl Abstract/FREE Full Text

[182] Brooks AJ,

[183] Smith PJ,

[184] Cohen R,

[185] et al.

[186] 42.↵
Hawthorne AB,
Glatter J,
Blackwell J,
et al.
(2022) Inflammatory bowel disease patient-reported quality assessment should drive service improvement: a national survey of UK IBD units and patients. Aliment Pharmacol Ther 56, 4, 625–645.
OpenUrl

[187] Hawthorne AB,

[188] Glatter J,

[189] Blackwell J,

[190] et al.

[191] 43.↵
Crohn’s & Colitis UK
(2019) RCGP IBD Spotlight Report to enter its third year. https://crohnsandcolitis.org.uk/our-work/healthcare-professionals/the-healthcare-professional-blog/the-healthcare-professional-blog/rcgp-ibd-spotlight-report-to-enter-its-third-year (accessed 15 Aug 2023).

[192] Crohn’s & Colitis UK

[193] 44.↵
Matsui D
(2013) Medication adherence issues in patients: focus on cost. Clinical Audit 5, 33–42.
OpenUrl

[194] Matsui D

[195] 45.↵
Hex N,
Mahon J,
Webb A
(2018) Economic evaluation of the benefits of extending free prescriptions to people with long-term conditions, https://www.prescriptionchargescoalition.org.uk/uploads/1/2/7/5/12754304/economic_evaluation_report.pdf (accessed 15 Aug 2023).

[196] Hex N,

[197] Mahon J,

[198] Webb A

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Adherence to 5-aminosalicylic acid maintenance treatment in young people with ulcerative colitis: a retrospective cohort study in primary care

Abstract

INTRODUCTION

METHOD

Data source

Case definition and cohort construction

Outcomes

Predictors of oral 5-ASA discontinuation and adherence

Data analysis

RESULTS

Risk and protective factors for oral 5-ASA discontinuation and adherence

DISCUSSION

Summary

Strengths and limitations

Comparison with existing literature

Implications for research and practice

Notes

Funding

Ethical approval

Data

Provenance

Competing interests

Contributors

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