Clinical assessment | | | | | | |
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Number in cohort | 6057 | 6089 | 2464 | 587 | 728 | 197 |
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Severity of sore throat/difficulty swallowing on a 4-point Likert scale, mean (SD) | 2.93 (0.72) | 3.32 (0.63) | 3.06 (0.70) | 2.93 (0.68) | 3.35 (0.63) | 3.01 (0.68) |
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Severity of all baseline symptomsa on 4-point Likert scale, mean (SD) | 1.89 (0.39) | 2.19 (0.39) | 1.99 (0.40) | 1.88 (0.40) | 2.21 (0.38) | 1.95 (0.36) |
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Mean FeverPAIN score, mean (SD) | 0.33 (0.58) | 1.21 (1.09) | 0.72 (0.84) | 0.26 (0.52) | 1.19 (1.11) | 0.73 (0.84) |
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Prior duration in days, mean (SD) | 4.96 (6.48) | 4.61 (4.10) | 4.29 (3.34) | 4.75 (4.14) | 4.57 (3.39) | 4.17 (3.15) |
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Age in years, mean (SD) | 34.72 (15.44) | 32.65 (14.18) | 34.07 (14.57) | 37.61 (15.47) | 36.04 (13.85) | 35.68 (14.15) |
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Female sex, n/N (%) | 3610/5243 (68.85) | 4147/6269 (66.15%) | 1770/2501 (70.77%) | 443/587 (75.47%) | 521/728 (71.57%) | 147/197 (74.62%) |
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Smoker, n/N (%) | 1016/5212 (19.49) | 1445/6240 (23.16%) | 481/2484 (19.36%) | 89/594 (15.24%) | 127/726 (17.49%) | 22/194 (11.34%) |
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Fever in last 24 hours, n/N (%) | 2279/4852 (46.97) | 4109/5704 (72.04%) | 1268/2317 (54.73%) | 261/585 (44.62%) | 515/724 (71.13%) | 113/197 (57.36%) |
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Temperature ºC (SD) | 36.66 (0.61) | 37.00 (0.75) | 36.77 (0.62) | 36.64 (0.61) | 36.99 (0.74) | 36.74 (0.50) |
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Pus on tonsils, n/N (%) | 376/5213 (7.21) | 3751/6232 (60.19%) | 654/2495 (26.21%) | 30/581 (5.16%) | 418/721 (57.98%) | 50/197 (25.38%) |
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Severely inflamed tonsils, n/N (%) | 86/4923 (1.75) | 1418/5855 (24.22%) | 178/2344 (7.59%) | 6/572 (1.05%) | 181/720 (25.14%) | 12/191 (6.28%) |
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Number of prior medical problems | 0.22 (0.49) | 0.24 (0.51) | 0.17 (0.43) | 0.28 (0.55) | 0.24 (0.51) | 0.17 (0.39) |
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Return within 4 weeks with new or worsening symptoms, n/N (%) | 803/4974 (16.14) | 864/5932 (14.57%) | 222/2382 (9.49%) | 107/564 (18.97%) | 101/694 (14.55%) | 24/186 (12.90%) |
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Return within 4 weeks with complications, n/N (%) | 75/4974 (1.51) | 78/5932 (1.31%) | 21/2382 (0.88%) | 12/564 (2.13%) | 8/694 (1.15%) | 3/186 (1.15%) |
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Individual complications, n/N (%) | | | | | | |
Quinsy | 11/4974 (0.22) | 30/5932 (0.52%) | 6/2382 (0.26%) | 4/564 (0.71%) | 3/694 (0.43%) | 1/186 (0.54%) |
Sinusitis | 23/4974 (0.46) | 12/5932 (0.21%) | 3/2382 (0.13%) | 2/564 (0.35%) | 0/694 | 0/186 |
Otitis media | 31/4974 (0.62) | 27/5932 (0.47%) | 11/2382 (0.47%) | 5/564 (0.89%) | 5/694 (0.72%) | 2/186 (1.08%) |
Celluliltis/impetigo | 10/4974 (0.20) | 9/5932 (0.16%) | 1/2382 (0.04%) | 1/564 (0.18%) | 0/694 | 0/186 |