Medical treatment for heavy menstrual bleeding in primary care: ten-year data from the ECLIPSE trial

Abstract

BACKGROUND: Heavy menstrual bleeding (HMB) is a common problem that can significantly affect women’s lives. There is a lack of evidence on long-term outcomes after seeking treatment. AIM: To assess continuation rates of medical treatments, and rates of surgery, in women 10 years after initial management for HMB in primary care. DESIGN: Prospective observational cohort study. METHODS: Women with HMB who participated in the ECLIPSE primary care trial (ISRCTN86566246) completed questionnaires 10 years after randomisation to levonorgestrel-releasing intra-uterine system (LNG-IUS) or to other usual medical treatments (oral tranexamic acid, mefenamic acid, combined oestrogen–progestogen; or progesterone alone). Outcomes were rates of surgery, medical treatments and quality of life using SF-36 and EQ-5D. RESULTS: The responding cohort of 206 women was demographically and clinically representative of the original trial population. Mean age at baseline was 41.9 (SD 4.9) and 53.7 years (SD 5.1) at follow up. Over the 10-year follow-up, 60 of 206 (29%) women had surgery (hysterectomy 34 [17%], endometrial ablation 26 [13%]). Between 5 and 10 years, 89 women (43%) ceased all medical treatments and 88 (43%) used LNG-IUS alone or in combination with other treatments. Fifty-six women (28%) were using LNG-IUS at 10 years. There were improvements over time in quality of life scores, with no evidence of differences in these or other outcomes between the two groups. CONCLUSIONS: Medical treatments for women with HMB can be successfully initiated in primary care, with low rates of surgery and improvement in quality of life observed a decade later.