TY - JOUR T1 - Double blind trial of clonidine in the treatment of migraine in a general practice JF - The Journal of the Royal College of General Practitioners JO - J R Coll Gen Pract SP - 587 LP - 590 VL - 28 IS - 195 AU - E. I. Adam AU - Sheila M. Gore AU - W. H. Price Y1 - 1978/10/01 UR - http://bjgp.org/content/28/195/587.abstract N2 - The value of clonidine (`Dixarit') for the prophylaxis of migraine has been assessed by a double blind cross-over trial. A dose of up to 0·15 mg daily was used. No effect on the frequency of the headaches could be detected over and above the 60 per cent reduction observed with a placebo. Severity, assessed subjectively by the patient, when it varied between placebo and clonidine, was less with clonidine (p<0·01). There was also some evidence that headaches lasting more than 12 hours were less common during treatment with the drug. ER -